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Atomistry » Fluorine » PDB 4u80-4uwf » 4u80 » |
Fluorine in PDB 4u80: Mek 1 Kinase Bound to G799Enzymatic activity of Mek 1 Kinase Bound to G799
All present enzymatic activity of Mek 1 Kinase Bound to G799:
2.7.12.2; Protein crystallography data
The structure of Mek 1 Kinase Bound to G799, PDB code: 4u80
was solved by
M.H.Ultsch,
K.D.Robarge,
C.Weismann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4u80:
The structure of Mek 1 Kinase Bound to G799 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Mek 1 Kinase Bound to G799
(pdb code 4u80). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Mek 1 Kinase Bound to G799, PDB code: 4u80: Fluorine binding site 1 out of 1 in 4u80Go back to Fluorine Binding Sites List in 4u80
Fluorine binding site 1 out
of 1 in the Mek 1 Kinase Bound to G799
Mono view Stereo pair view
Reference:
K.D.Robarge,
W.Lee,
C.Eigenbrot,
M.Ultsch,
C.Wiesmann,
R.Heald,
S.Price,
J.Hewitt,
P.Jackson,
P.Savy,
B.Burton,
E.F.Choo,
J.Pang,
J.Boggs,
A.Yang,
X.Yang,
M.Baumgardner.
Structure Based Design of Novel 6,5 Heterobicyclic Mitogen-Activated Protein Kinase Kinase (Mek) Inhibitors Leading to the Discovery of Imidazo[1,5-A] Pyrazine G-479. Bioorg.Med.Chem.Lett. V. 24 4714 2014.
Page generated: Sun Dec 13 12:13:05 2020
ISSN: ESSN 1464-3405 PubMed: 25193232 DOI: 10.1016/J.BMCL.2014.08.008 |
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