Fluorine in PDB 4uce: N-Terminal Globular Domain of the Rsv Nucleoprotein in Complex with the Nucleoprotein Phosphoprotein Interaction Inhibitor M72

The structure of N-Terminal Globular Domain of the Rsv Nucleoprotein in Complex with the Nucleoprotein Phosphoprotein Interaction Inhibitor M72, PDB code: 4uce was solved by M.Ouizougun-Oubari, N.Pereira, B.Tarus, M.Galloux, M.-A.Tortorici, S.Hoos, B.Baron, P.England, F.Bontems, F.A.Rey, J.-F.Eleouet, C.Sizun, A.Slama-Schwok, S.Duquerroy, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.95
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	34.050, 71.350, 178.400, 90.00, 90.00, 90.00
R / Rfree (%)	20.32 / 24.01

The binding sites of Fluorine atom in the N-Terminal Globular Domain of the Rsv Nucleoprotein in Complex with the Nucleoprotein Phosphoprotein Interaction Inhibitor M72 (pdb code 4uce). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the N-Terminal Globular Domain of the Rsv Nucleoprotein in Complex with the Nucleoprotein Phosphoprotein Interaction Inhibitor M72, PDB code: 4uce:

Fluorine binding site 1 out of 1 in the N-Terminal Globular Domain of the Rsv Nucleoprotein in Complex with the Nucleoprotein Phosphoprotein Interaction Inhibitor M72


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of N-Terminal Globular Domain of the Rsv Nucleoprotein in Complex with the Nucleoprotein Phosphoprotein Interaction Inhibitor M72 within 5.0Å range: probe atom residue distance (Å) B Occ A:F301 b:0.6 occ:1.00 F A:MZS301 0.0 0.6 1.0 C2 A:MZS301 1.4 0.6 1.0 C1 A:MZS301 2.3 0.2 1.0 C3 A:MZS301 2.3 99.0 1.0 H3 A:MZS301 2.6 97.7 1.0 H1 A:MZS301 2.6 0.5 1.0 OG A:SER131 2.6 54.8 1.0 CB A:SER131 3.2 43.2 1.0 C A:SER131 3.3 42.1 1.0 N A:ARG132 3.5 35.6 1.0 O A:SER131 3.6 42.2 1.0 C A:MZS301 3.6 0.2 1.0 C4 A:MZS301 3.6 0.6 1.0 CD1 A:ILE53 3.8 45.5 1.0 CA A:SER131 3.9 41.7 1.0 CA A:ARG132 4.0 35.6 1.0 CG A:MET50 4.0 43.5 1.0 C5 A:MZS301 4.1 0.9 1.0 CG A:HIS151 4.1 46.8 1.0 CG A:ARG132 4.2 47.2 1.0 ND1 A:HIS151 4.2 49.3 1.0 O A:GLU128 4.4 56.2 1.0 CD2 A:HIS151 4.4 48.0 1.0 H A:MZS301 4.4 0.5 1.0 H4 A:MZS301 4.5 100.0 1.0 SD A:MET50 4.5 49.9 1.0 CB A:HIS151 4.5 43.8 1.0 CE1 A:HIS151 4.5 49.8 1.0 CB A:TYR135 4.6 45.2 1.0 CG1 A:ILE53 4.6 43.0 1.0 CB A:ARG132 4.7 36.1 1.0 NE2 A:HIS151 4.7 49.3 1.0 CB A:MET50 4.7 39.6 1.0 CA A:MET50 4.9 37.3 1.0 N A:SER131 4.9 44.8 1.0

M.Ouizougun-Oubari, N.Pereira, B.Tarus, M.Galloux, S.Lassoued, J.Fix, M.A.Tortorici, S.Hoos, B.Baron, P.England, D.Desmaele, P.Couvreur, F.Bontems, F.A.Rey, J.F.Eleouet, C.Sizun, A.Slama-Schwok, S.Duquerroy. A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of the Human Respiratory Syncytial Virus. J.Virol. V. 89 11129 2015.
ISSN: ISSN 0022-538X
PubMed: 26246564
DOI: 10.1128/JVI.01612-15