Fluorine in PDB 4uqj: Cryo-Em Density Map of GLUA2EM in Complex with ZK200775

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Fluorine atom in the Cryo-Em Density Map of GLUA2EM in Complex with ZK200775 (pdb code 4uqj). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the Cryo-Em Density Map of GLUA2EM in Complex with ZK200775, PDB code: 4uqj:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in the Cryo-Em Density Map of GLUA2EM in Complex with ZK200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Density Map of GLUA2EM in Complex with ZK200775 within 5.0Å range: probe atom residue distance (Å) B Occ A:F833 b:0.0 occ:1.00 FAF A:ZK1833 0.0 0.0 1.0 CAZ A:ZK1833 1.4 0.0 1.0 FAG A:ZK1833 2.2 0.0 1.0 FAH A:ZK1833 2.2 0.0 1.0 CAS A:ZK1833 2.4 0.0 1.0 OH A:TYR732 3.1 0.0 1.0 OG1 A:THR707 3.1 0.0 1.0 CAM A:ZK1833 3.2 0.0 1.0 CAR A:ZK1833 3.2 0.0 1.0 CAJ A:ZK1833 3.3 0.0 1.0 NAX A:ZK1833 3.3 0.0 1.0 CB A:GLU705 4.0 0.0 1.0 CB A:MET708 4.1 0.0 1.0 CAK A:ZK1833 4.3 0.0 1.0 CZ A:TYR732 4.3 0.0 1.0 N A:MET708 4.3 0.0 1.0 CB A:THR707 4.4 0.0 1.0 CAI A:ZK1833 4.4 0.0 1.0 CAN A:ZK1833 4.5 0.0 1.0 CAV A:ZK1833 4.5 0.0 1.0 CA A:MET708 4.7 0.0 1.0 OH A:TYR405 4.8 0.0 1.0 CE1 A:TYR405 4.8 0.0 1.0 CE2 A:TYR732 5.0 0.0 1.0 CAW A:ZK1833 5.0 0.0 1.0

Fluorine binding site 2 out of 12 in the Cryo-Em Density Map of GLUA2EM in Complex with ZK200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Density Map of GLUA2EM in Complex with ZK200775 within 5.0Å range: probe atom residue distance (Å) B Occ A:F833 b:0.0 occ:1.00 FAG A:ZK1833 0.0 0.0 1.0 CAZ A:ZK1833 1.4 0.0 1.0 FAH A:ZK1833 2.2 0.0 1.0 FAF A:ZK1833 2.2 0.0 1.0 CAS A:ZK1833 2.4 0.0 1.0 CAJ A:ZK1833 2.7 0.0 1.0 CB A:PRO478 3.5 0.0 1.0 CE1 A:TYR405 3.6 0.0 1.0 OH A:TYR732 3.6 0.0 1.0 CAR A:ZK1833 3.6 0.0 1.0 OH A:TYR450 3.7 0.0 1.0 CG A:PRO478 3.8 0.0 1.0 CG A:GLU402 3.9 0.0 1.0 CAV A:ZK1833 4.1 0.0 1.0 CD1 A:TYR405 4.2 0.0 1.0 NAX A:ZK1833 4.2 0.0 1.0 CZ A:TYR732 4.2 0.0 1.0 CZ A:TYR405 4.2 0.0 1.0 OH A:TYR405 4.4 0.0 1.0 OG1 A:THR707 4.5 0.0 1.0 CZ A:TYR450 4.7 0.0 1.0 CD A:GLU402 4.7 0.0 1.0 CE2 A:TYR732 4.7 0.0 1.0 CAM A:ZK1833 4.7 0.0 1.0 O A:PRO478 4.8 0.0 1.0 CAI A:ZK1833 4.8 0.0 1.0 CB A:GLU402 4.8 0.0 1.0 CE1 A:TYR732 4.9 0.0 1.0 OE2 A:GLU402 4.9 0.0 1.0 CAW A:ZK1833 5.0 0.0 1.0 NAP A:ZK1833 5.0 0.0 1.0 CA A:PRO478 5.0 0.0 1.0 CAN A:ZK1833 5.0 0.0 1.0

Fluorine binding site 3 out of 12 in the Cryo-Em Density Map of GLUA2EM in Complex with ZK200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Density Map of GLUA2EM in Complex with ZK200775 within 5.0Å range: probe atom residue distance (Å) B Occ A:F833 b:0.0 occ:1.00 FAH A:ZK1833 0.0 0.0 1.0 CAZ A:ZK1833 1.4 0.0 1.0 FAG A:ZK1833 2.2 0.0 1.0 FAF A:ZK1833 2.2 0.0 1.0 CAS A:ZK1833 2.4 0.0 1.0 NAX A:ZK1833 2.6 0.0 1.0 CAR A:ZK1833 2.8 0.0 1.0 CAN A:ZK1833 3.1 0.0 1.0 CAM A:ZK1833 3.2 0.0 1.0 OE2 A:GLU402 3.3 0.0 1.0 CG A:GLU402 3.4 0.0 1.0 CD A:GLU402 3.6 0.0 1.0 CAJ A:ZK1833 3.6 0.0 1.0 OH A:TYR450 3.9 0.0 1.0 CAK A:ZK1833 3.9 0.0 1.0 CAL A:ZK1833 4.0 0.0 1.0 CAI A:ZK1833 4.2 0.0 1.0 SD A:MET708 4.3 0.0 1.0 CB A:MET708 4.4 0.0 1.0 OE1 A:GLU402 4.5 0.0 1.0 OAQ A:ZK1833 4.6 0.0 1.0 CG A:MET708 4.6 0.0 1.0 CAV A:ZK1833 4.8 0.0 1.0 CB A:GLU402 4.8 0.0 1.0 CE1 A:TYR405 5.0 0.0 1.0

Fluorine binding site 4 out of 12 in the Cryo-Em Density Map of GLUA2EM in Complex with ZK200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Density Map of GLUA2EM in Complex with ZK200775 within 5.0Å range: probe atom residue distance (Å) B Occ B:F833 b:0.0 occ:1.00 FAF B:ZK1833 0.0 0.0 1.0 CAZ B:ZK1833 1.4 0.0 1.0 FAG B:ZK1833 2.2 0.0 1.0 FAH B:ZK1833 2.2 0.0 1.0 CAS B:ZK1833 2.4 0.0 1.0 OH B:TYR732 3.0 0.0 1.0 CAM B:ZK1833 3.2 0.0 1.0 OG1 B:THR707 3.2 0.0 1.0 CAR B:ZK1833 3.2 0.0 1.0 CAJ B:ZK1833 3.3 0.0 1.0 NAX B:ZK1833 3.3 0.0 1.0 CB B:GLU705 4.1 0.0 1.0 CZ B:TYR732 4.2 0.0 1.0 CB B:MET708 4.2 0.0 1.0 CAK B:ZK1833 4.3 0.0 1.0 N B:MET708 4.4 0.0 1.0 CB B:THR707 4.4 0.0 1.0 CAI B:ZK1833 4.4 0.0 1.0 CAN B:ZK1833 4.5 0.0 1.0 CAV B:ZK1833 4.5 0.0 1.0 CE1 B:TYR405 4.8 0.0 1.0 OH B:TYR405 4.8 0.0 1.0 CA B:MET708 4.8 0.0 1.0 CE2 B:TYR732 4.9 0.0 1.0 CAW B:ZK1833 5.0 0.0 1.0

Fluorine binding site 5 out of 12 in the Cryo-Em Density Map of GLUA2EM in Complex with ZK200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Density Map of GLUA2EM in Complex with ZK200775 within 5.0Å range: probe atom residue distance (Å) B Occ B:F833 b:0.0 occ:1.00 FAG B:ZK1833 0.0 0.0 1.0 CAZ B:ZK1833 1.4 0.0 1.0 FAH B:ZK1833 2.2 0.0 1.0 FAF B:ZK1833 2.2 0.0 1.0 CAS B:ZK1833 2.4 0.0 1.0 CAJ B:ZK1833 2.7 0.0 1.0 CB B:PRO478 3.3 0.0 1.0 CE1 B:TYR405 3.5 0.0 1.0 OH B:TYR732 3.6 0.0 1.0 CAR B:ZK1833 3.6 0.0 1.0 CG B:PRO478 3.7 0.0 1.0 OH B:TYR450 3.8 0.0 1.0 CG B:GLU402 4.0 0.0 1.0 CD1 B:TYR405 4.1 0.0 1.0 CZ B:TYR732 4.1 0.0 1.0 CZ B:TYR405 4.1 0.0 1.0 CAV B:ZK1833 4.1 0.0 1.0 NAX B:ZK1833 4.2 0.0 1.0 OH B:TYR405 4.3 0.0 1.0 OG1 B:THR707 4.4 0.0 1.0 CE2 B:TYR732 4.6 0.0 1.0 O B:PRO478 4.6 0.0 1.0 CZ B:TYR450 4.7 0.0 1.0 CAM B:ZK1833 4.7 0.0 1.0 CE1 B:TYR732 4.8 0.0 1.0 CAI B:ZK1833 4.8 0.0 1.0 CA B:PRO478 4.8 0.0 1.0 CD B:GLU402 4.8 0.0 1.0 CB B:GLU402 4.9 0.0 1.0 CD B:PRO478 4.9 0.0 1.0 CAW B:ZK1833 5.0 0.0 1.0 NAP B:ZK1833 5.0 0.0 1.0 CAN B:ZK1833 5.0 0.0 1.0

Fluorine binding site 6 out of 12 in the Cryo-Em Density Map of GLUA2EM in Complex with ZK200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Density Map of GLUA2EM in Complex with ZK200775 within 5.0Å range: probe atom residue distance (Å) B Occ B:F833 b:0.0 occ:1.00 FAH B:ZK1833 0.0 0.0 1.0 CAZ B:ZK1833 1.4 0.0 1.0 FAG B:ZK1833 2.2 0.0 1.0 FAF B:ZK1833 2.2 0.0 1.0 CAS B:ZK1833 2.4 0.0 1.0 NAX B:ZK1833 2.6 0.0 1.0 CAR B:ZK1833 2.8 0.0 1.0 CAN B:ZK1833 3.1 0.0 1.0 CAM B:ZK1833 3.2 0.0 1.0 CG B:GLU402 3.3 0.0 1.0 OE2 B:GLU402 3.3 0.0 1.0 CD B:GLU402 3.5 0.0 1.0 CAJ B:ZK1833 3.6 0.0 1.0 OH B:TYR450 3.7 0.0 1.0 CAK B:ZK1833 3.9 0.0 1.0 CAL B:ZK1833 4.0 0.0 1.0 CAI B:ZK1833 4.2 0.0 1.0 SD B:MET708 4.4 0.0 1.0 OE1 B:GLU402 4.4 0.0 1.0 CB B:MET708 4.5 0.0 1.0 OAQ B:ZK1833 4.6 0.0 1.0 CB B:GLU402 4.7 0.0 1.0 CG B:MET708 4.8 0.0 1.0 CAV B:ZK1833 4.8 0.0 1.0 CE1 B:TYR405 4.8 0.0 1.0 CZ B:TYR450 4.9 0.0 1.0 OH B:TYR732 5.0 0.0 1.0

Fluorine binding site 7 out of 12 in the Cryo-Em Density Map of GLUA2EM in Complex with ZK200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Cryo-Em Density Map of GLUA2EM in Complex with ZK200775 within 5.0Å range: probe atom residue distance (Å) B Occ C:F833 b:0.0 occ:1.00 FAF C:ZK1833 0.0 0.0 1.0 CAZ C:ZK1833 1.4 0.0 1.0 FAG C:ZK1833 2.2 0.0 1.0 FAH C:ZK1833 2.2 0.0 1.0 CAS C:ZK1833 2.4 0.0 1.0 OH C:TYR732 3.1 0.0 1.0 CAM C:ZK1833 3.1 0.0 1.0 CAR C:ZK1833 3.2 0.0 1.0 CAJ C:ZK1833 3.3 0.0 1.0 OG1 C:THR707 3.3 0.0 1.0 NAX C:ZK1833 3.3 0.0 1.0 CB C:MET708 4.2 0.0 1.0 CAK C:ZK1833 4.3 0.0 1.0 CZ C:TYR732 4.3 0.0 1.0 CB C:GLU705 4.3 0.0 1.0 CAI C:ZK1833 4.4 0.0 1.0 CAN C:ZK1833 4.5 0.0 1.0 N C:MET708 4.5 0.0 1.0 CAV C:ZK1833 4.5 0.0 1.0 CB C:THR707 4.6 0.0 1.0 CE1 C:TYR405 4.7 0.0 1.0 OH C:TYR405 4.8 0.0 1.0 CA C:MET708 4.9 0.0 1.0 CE2 C:TYR732 4.9 0.0 1.0 OH C:TYR450 5.0 0.0 1.0 CAW C:ZK1833 5.0 0.0 1.0

Fluorine binding site 8 out of 12 in the Cryo-Em Density Map of GLUA2EM in Complex with ZK200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Cryo-Em Density Map of GLUA2EM in Complex with ZK200775 within 5.0Å range: probe atom residue distance (Å) B Occ C:F833 b:0.0 occ:1.00 FAG C:ZK1833 0.0 0.0 1.0 CAZ C:ZK1833 1.4 0.0 1.0 FAH C:ZK1833 2.2 0.0 1.0 FAF C:ZK1833 2.2 0.0 1.0 CAS C:ZK1833 2.4 0.0 1.0 CAJ C:ZK1833 2.7 0.0 1.0 CB C:PRO478 3.3 0.0 1.0 OH C:TYR450 3.6 0.0 1.0 CG C:PRO478 3.6 0.0 1.0 CE1 C:TYR405 3.6 0.0 1.0 CAR C:ZK1833 3.6 0.0 1.0 OH C:TYR732 3.8 0.0 1.0 CG C:GLU402 3.8 0.0 1.0 CD1 C:TYR405 4.1 0.0 1.0 CAV C:ZK1833 4.1 0.0 1.0 CZ C:TYR405 4.2 0.0 1.0 NAX C:ZK1833 4.2 0.0 1.0 CZ C:TYR732 4.3 0.0 1.0 OH C:TYR405 4.4 0.0 1.0 CZ C:TYR450 4.5 0.0 1.0 O C:PRO478 4.6 0.0 1.0 CD C:GLU402 4.6 0.0 1.0 CB C:GLU402 4.7 0.0 1.0 OG1 C:THR707 4.7 0.0 1.0 CAM C:ZK1833 4.7 0.0 1.0 CA C:PRO478 4.8 0.0 1.0 CE2 C:TYR732 4.8 0.0 1.0 CAI C:ZK1833 4.8 0.0 1.0 CD C:PRO478 4.8 0.0 1.0 CE1 C:TYR450 4.9 0.0 1.0 CE1 C:TYR732 4.9 0.0 1.0 OE2 C:GLU402 5.0 0.0 1.0 CAW C:ZK1833 5.0 0.0 1.0 NAP C:ZK1833 5.0 0.0 1.0 CAN C:ZK1833 5.0 0.0 1.0

Fluorine binding site 9 out of 12 in the Cryo-Em Density Map of GLUA2EM in Complex with ZK200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Cryo-Em Density Map of GLUA2EM in Complex with ZK200775 within 5.0Å range: probe atom residue distance (Å) B Occ C:F833 b:0.0 occ:1.00 FAH C:ZK1833 0.0 0.0 1.0 CAZ C:ZK1833 1.4 0.0 1.0 FAG C:ZK1833 2.2 0.0 1.0 FAF C:ZK1833 2.2 0.0 1.0 CAS C:ZK1833 2.4 0.0 1.0 NAX C:ZK1833 2.6 0.0 1.0 CAR C:ZK1833 2.8 0.0 1.0 CAN C:ZK1833 3.1 0.0 1.0 CG C:GLU402 3.1 0.0 1.0 OE2 C:GLU402 3.2 0.0 1.0 CAM C:ZK1833 3.2 0.0 1.0 CD C:GLU402 3.3 0.0 1.0 OH C:TYR450 3.6 0.0 1.0 CAJ C:ZK1833 3.6 0.0 1.0 CAK C:ZK1833 3.9 0.0 1.0 CAL C:ZK1833 4.0 0.0 1.0 CAI C:ZK1833 4.2 0.0 1.0 OE1 C:GLU402 4.2 0.0 1.0 CB C:GLU402 4.5 0.0 1.0 SD C:MET708 4.5 0.0 1.0 OAQ C:ZK1833 4.6 0.0 1.0 CB C:MET708 4.7 0.0 1.0 CZ C:TYR450 4.7 0.0 1.0 CAV C:ZK1833 4.8 0.0 1.0 CE1 C:TYR405 4.9 0.0 1.0 CG C:MET708 4.9 0.0 1.0

Fluorine binding site 10 out of 12 in the Cryo-Em Density Map of GLUA2EM in Complex with ZK200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Cryo-Em Density Map of GLUA2EM in Complex with ZK200775 within 5.0Å range: probe atom residue distance (Å) B Occ D:F833 b:0.0 occ:1.00 FAF D:ZK1833 0.0 0.0 1.0 CAZ D:ZK1833 1.4 0.0 1.0 FAG D:ZK1833 2.2 0.0 1.0 FAH D:ZK1833 2.2 0.0 1.0 CAS D:ZK1833 2.4 0.0 1.0 OH D:TYR732 2.8 0.0 1.0 CAM D:ZK1833 3.1 0.0 1.0 CAR D:ZK1833 3.2 0.0 1.0 OG1 D:THR707 3.2 0.0 1.0 CAJ D:ZK1833 3.3 0.0 1.0 NAX D:ZK1833 3.3 0.0 1.0 CZ D:TYR732 4.0 0.0 1.0 CB D:GLU705 4.1 0.0 1.0 CAK D:ZK1833 4.3 0.0 1.0 CB D:MET708 4.4 0.0 1.0 CAI D:ZK1833 4.4 0.0 1.0 CB D:THR707 4.5 0.0 1.0 CAN D:ZK1833 4.5 0.0 1.0 CAV D:ZK1833 4.5 0.0 1.0 N D:MET708 4.6 0.0 1.0 CE2 D:TYR732 4.7 0.0 1.0 CE1 D:TYR732 4.8 0.0 1.0 OH D:TYR405 4.8 0.0 1.0 CE1 D:TYR405 4.9 0.0 1.0 CAW D:ZK1833 5.0 0.0 1.0

J.R.Meyerson, J.Kumar, S.Chittori, P.Rao, J.Pierson, A.Bartesaghi, M.L.Mayer, S.Subramaniam. Structural Mechanism of Glutamate Receptor Activation and Desensitization Nature V. 514 328 2014.
ISSN: ISSN 0028-0836
PubMed: 25119039
DOI: 10.1038/NATURE13603