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Atomistry » Fluorine » PDB 4uwg-4whq » 4uwj | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4uwg-4whq » 4uwj » |
Fluorine in PDB 4uwj: Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Capped Pyrazole Sulphonamide LigandEnzymatic activity of Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Capped Pyrazole Sulphonamide Ligand
All present enzymatic activity of Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Capped Pyrazole Sulphonamide Ligand:
2.3.1.97; Protein crystallography data
The structure of Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Capped Pyrazole Sulphonamide Ligand, PDB code: 4uwj
was solved by
D.A.Robinson,
S.Brand,
N.R.Norcross,
S.Thompson,
J.R.Harrison,
V.C.Smith,
L.S.Torrie,
S.P.Mcelroy,
I.Hallyburton,
S.Norval,
L.Stojanovski,
F.R.C.Simeons,
J.A.Frearson,
R.Brenk,
A.H.Fairlamb,
M.A.J.Ferguson,
P.G.Wyatt,
I.H.Gilbert,
K.D.Read,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4uwj:
The structure of Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Capped Pyrazole Sulphonamide Ligand also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Capped Pyrazole Sulphonamide Ligand
(pdb code 4uwj). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Capped Pyrazole Sulphonamide Ligand, PDB code: 4uwj: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 4uwjGo back to Fluorine Binding Sites List in 4uwj
Fluorine binding site 1 out
of 2 in the Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Capped Pyrazole Sulphonamide Ligand
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 4uwjGo back to Fluorine Binding Sites List in 4uwj
Fluorine binding site 2 out
of 2 in the Crystal Structure of Aspergillus Fumigatus N-Myristoyl Transferase in Complex with Myristoyl Coa and A Capped Pyrazole Sulphonamide Ligand
Mono view Stereo pair view
Reference:
S.Brand,
N.R.Norcross,
S.Thompson,
J.R.Harrison,
V.C.Smith,
D.A.Robinson,
L.S.Torrie,
S.P.Mcelroy,
I.Hallyburton,
S.Norval,
P.Scullion,
L.Stojanovski,
F.R.C.Simeons,
D.Van Aalten,
J.A.Frearson,
R.Brenk,
A.H.Fairlamb,
M.A.J.Ferguson,
P.G.Wyatt,
I.H.Gilbert,
K.D.Read.
Lead Optimization of A Pyrazole Sulfonamide Series of Trypanosoma Brucei N-Myristoyltransferase Inhibitors: Identification and Evaluation of Cns Penetrant Compounds As Potential Treatments For Stage 2 Human African Trypanosomiasis. J.Med.Chem. 2014.
Page generated: Thu Aug 1 06:15:10 2024
ISSN: ESSN 1520-4804 PubMed: 25412409 DOI: 10.1021/JM500809C |
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