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Atomistry » Fluorine » PDB 4uwg-4whq » 4uxl » |
Fluorine in PDB 4uxl: Structure of Human ROS1 Kinase Domain in Complex with Pf-06463922Enzymatic activity of Structure of Human ROS1 Kinase Domain in Complex with Pf-06463922
All present enzymatic activity of Structure of Human ROS1 Kinase Domain in Complex with Pf-06463922:
2.7.10.1; Protein crystallography data
The structure of Structure of Human ROS1 Kinase Domain in Complex with Pf-06463922, PDB code: 4uxl
was solved by
M.Mctigue,
Y.Deng,
W.Liu,
A.Brooun,
A.Stewart,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Human ROS1 Kinase Domain in Complex with Pf-06463922
(pdb code 4uxl). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of Human ROS1 Kinase Domain in Complex with Pf-06463922, PDB code: 4uxl: Fluorine binding site 1 out of 1 in 4uxlGo back to Fluorine Binding Sites List in 4uxl
Fluorine binding site 1 out
of 1 in the Structure of Human ROS1 Kinase Domain in Complex with Pf-06463922
Mono view Stereo pair view
Reference:
H.Zou,
Q.Li,
L.D.Engstrom,
M.West,
V.Appleman,
K.A.Wong,
M.Mctigue,
Y.L.Deng,
W.Liu,
A.Brooun,
S.Timofeevski,
S.R.P.Mcdonell,
P.Jiang,
M.D.Falk,
P.B.Lappin,
T.Affolter,
T.Nichols,
W.Hu,
J.Lam,
T.W.Johnson,
T.Smeal,
A.Charest,
V.R.Fantin.
Pf-06463922 Is A Potent and Selective Next-Generation ROS1/Alk Inhibitor Capable of Blocking Crizotinib-Resistant ROS1 Mutations Proc.Natl.Acad.Sci.Usa 2015.
Page generated: Sun Dec 13 12:13:42 2020
ISSN: ESSN 1091-6490 DOI: 10.1073/PNAS.1420785112 |
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