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Atomistry » Fluorine » PDB 4uwg-4whq » 4uxq | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4uwg-4whq » 4uxq » |
Fluorine in PDB 4uxq: FGFR4 in Complex with PonatinibEnzymatic activity of FGFR4 in Complex with Ponatinib
All present enzymatic activity of FGFR4 in Complex with Ponatinib:
2.7.10.1; Protein crystallography data
The structure of FGFR4 in Complex with Ponatinib, PDB code: 4uxq
was solved by
J.Tucker,
T.Klein,
J.Breed,
A.Breeze,
R.Overman,
C.Phillips,
R.A.Norman,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the FGFR4 in Complex with Ponatinib
(pdb code 4uxq). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the FGFR4 in Complex with Ponatinib, PDB code: 4uxq: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 4uxqGo back to Fluorine Binding Sites List in 4uxq
Fluorine binding site 1 out
of 3 in the FGFR4 in Complex with Ponatinib
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 4uxqGo back to Fluorine Binding Sites List in 4uxq
Fluorine binding site 2 out
of 3 in the FGFR4 in Complex with Ponatinib
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 4uxqGo back to Fluorine Binding Sites List in 4uxq
Fluorine binding site 3 out
of 3 in the FGFR4 in Complex with Ponatinib
Mono view Stereo pair view
Reference:
J.Tucker,
T.Klein,
J.Breed,
A.Breeze,
R.Overman,
C.Phillips,
R.A.Norman.
Structural Insights Into Fgfr Kinase Isoform Selectivity: Diverse Binding Modes of AZD4547 and Ponatinib with FGFR1 and FGFR4 To Be Published.
Page generated: Sun Dec 13 12:13:42 2020
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