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Atomistry » Fluorine » PDB 4uwg-4whq » 4w4x » |
Fluorine in PDB 4w4x: JNK2/3 in Complex with 3-(4-{[(4-Fluorophenyl)Carbamoyl]Amino}-1H- Pyrazol-1-Yl)-N-(2-Methylpyridin-4-Yl)BenzamideEnzymatic activity of JNK2/3 in Complex with 3-(4-{[(4-Fluorophenyl)Carbamoyl]Amino}-1H- Pyrazol-1-Yl)-N-(2-Methylpyridin-4-Yl)Benzamide
All present enzymatic activity of JNK2/3 in Complex with 3-(4-{[(4-Fluorophenyl)Carbamoyl]Amino}-1H- Pyrazol-1-Yl)-N-(2-Methylpyridin-4-Yl)Benzamide:
2.7.11.24; Protein crystallography data
The structure of JNK2/3 in Complex with 3-(4-{[(4-Fluorophenyl)Carbamoyl]Amino}-1H- Pyrazol-1-Yl)-N-(2-Methylpyridin-4-Yl)Benzamide, PDB code: 4w4x
was solved by
H.Park,
S.Iqbal,
P.Hernandez,
R.Mora,
K.Zheng,
Y.Feng,
P.Lograsso,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the JNK2/3 in Complex with 3-(4-{[(4-Fluorophenyl)Carbamoyl]Amino}-1H- Pyrazol-1-Yl)-N-(2-Methylpyridin-4-Yl)Benzamide
(pdb code 4w4x). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the JNK2/3 in Complex with 3-(4-{[(4-Fluorophenyl)Carbamoyl]Amino}-1H- Pyrazol-1-Yl)-N-(2-Methylpyridin-4-Yl)Benzamide, PDB code: 4w4x: Fluorine binding site 1 out of 1 in 4w4xGo back to Fluorine Binding Sites List in 4w4x
Fluorine binding site 1 out
of 1 in the JNK2/3 in Complex with 3-(4-{[(4-Fluorophenyl)Carbamoyl]Amino}-1H- Pyrazol-1-Yl)-N-(2-Methylpyridin-4-Yl)Benzamide
Mono view Stereo pair view
Reference:
H.Park,
S.Iqbal,
P.Hernandez,
R.Mora,
K.Zheng,
Y.Feng,
P.Lograsso.
Structural Basis and Biological Consequences For JNK2/3 Isoform Selective Aminopyrazoles. Sci Rep V. 5 8047 2015.
Page generated: Thu Aug 1 06:18:42 2024
ISSN: ESSN 2045-2322 PubMed: 25623238 DOI: 10.1038/SREP08047 |
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