Fluorine in PDB 4xg4: Crystal Structure of An Inhibitor-Bound Syk

All present enzymatic activity of Crystal Structure of An Inhibitor-Bound Syk:
2.7.10.2;

The structure of Crystal Structure of An Inhibitor-Bound Syk, PDB code: 4xg4 was solved by S.J.Lee, J.Choi, B.G.Han, H.Song, J.S.Koh, B.I.Lee, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.53 / 2.30
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	40.219, 85.056, 41.749, 90.00, 98.80, 90.00
R / Rfree (%)	19.4 / 22.8

The binding sites of Fluorine atom in the Crystal Structure of An Inhibitor-Bound Syk (pdb code 4xg4). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of An Inhibitor-Bound Syk, PDB code: 4xg4:

Fluorine binding site 1 out of 1 in the Crystal Structure of An Inhibitor-Bound Syk


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of An Inhibitor-Bound Syk within 5.0Å range: probe atom residue distance (Å) B Occ A:F701 b:35.1 occ:1.00 F5 A:X4G701 0.0 35.1 1.0 C5 A:X4G701 1.4 34.4 1.0 C6 A:X4G701 2.3 32.9 1.0 C4 A:X4G701 2.4 34.2 1.0 CAJ A:X4G701 2.8 33.7 1.0 NBG A:X4G701 2.9 34.9 1.0 SD A:MET448 3.6 29.8 1.0 N1 A:X4G701 3.6 33.3 1.0 CB A:ALA400 3.6 34.1 1.0 CG1 A:VAL433 3.6 31.1 1.0 CB A:MET448 3.6 30.6 1.0 N3 A:X4G701 3.6 34.0 1.0 O A:GLU449 3.8 31.1 1.0 CE A:MET448 3.8 29.8 1.0 C2 A:X4G701 4.1 33.6 1.0 CAX A:X4G701 4.2 34.2 1.0 CG A:MET448 4.2 30.8 1.0 CAK A:X4G701 4.3 34.5 1.0 CD1 A:LEU501 4.3 30.5 1.0 CG2 A:VAL433 4.6 31.4 1.0 CB A:VAL433 4.6 31.3 1.0 CA A:MET448 4.9 31.7 1.0 CA A:ALA400 4.9 34.8 1.0 CBA A:X4G701 4.9 34.3 1.0 O A:ALA400 4.9 35.5 1.0 C A:GLU449 5.0 31.8 1.0 C A:MET448 5.0 31.8 1.0

S.J.Lee, J.S.Choi, B.G.Han, H.S.Kim, H.J.Song, J.Lee, S.Nam, S.H.Goh, J.H.Kim, J.S.Koh, B.I.Lee. Crystal Structures of Spleen Tyrosine Kinase in Complex with Novel Inhibitors: Structural Insights For Design of Anticancer Drugs Febs J. V. 283 3613 2016.
ISSN: ISSN 1742-464X
PubMed: 27504936
DOI: 10.1111/FEBS.13831