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Atomistry » Fluorine » PDB 4x7j-4xxs » 4xhk | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4x7j-4xxs » 4xhk » |
Fluorine in PDB 4xhk: PIM1 Kinase in Complex with Compound 1SEnzymatic activity of PIM1 Kinase in Complex with Compound 1S
All present enzymatic activity of PIM1 Kinase in Complex with Compound 1S:
2.7.11.1; Protein crystallography data
The structure of PIM1 Kinase in Complex with Compound 1S, PDB code: 4xhk
was solved by
D.J.Marcotte,
L.F.Silvian,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the PIM1 Kinase in Complex with Compound 1S
(pdb code 4xhk). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the PIM1 Kinase in Complex with Compound 1S, PDB code: 4xhk: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 4xhkGo back to Fluorine Binding Sites List in 4xhk
Fluorine binding site 1 out
of 2 in the PIM1 Kinase in Complex with Compound 1S
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 4xhkGo back to Fluorine Binding Sites List in 4xhk
Fluorine binding site 2 out
of 2 in the PIM1 Kinase in Complex with Compound 1S
Mono view Stereo pair view
Reference:
A.Ishchenko,
L.Zhang,
J.Y.Le Brazidec,
J.Fan,
J.H.Chong,
A.Hingway,
A.Raditsis,
L.Singh,
B.Elenbaas,
V.S.Hong,
D.Marcotte,
L.Silvian,
I.Enyedy,
J.Chao.
Structure-Based Design of Low-Nanomolar Pim Kinase Inhibitors. Bioorg.Med.Chem.Lett. V. 25 474 2015.
Page generated: Sun Dec 13 12:15:00 2020
ISSN: ESSN 1464-3405 PubMed: 25575657 DOI: 10.1016/J.BMCL.2014.12.041 |
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