Fluorine in PDB 4xry: Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex
Enzymatic activity of Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex
All present enzymatic activity of Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex:
1.14.14.1;
Protein crystallography data
The structure of Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex, PDB code: 4xry
was solved by
E.F.Johnson,
Y.Fan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
39.16 /
2.50
|
Space group
|
P 21 21 21
|
Cell size a, b, c (Å), α, β, γ (°)
|
57.064,
192.341,
247.304,
90.00,
90.00,
90.00
|
R / Rfree (%)
|
20.8 /
25.1
|
Other elements in 4xry:
The structure of Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex
(pdb code 4xry). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the
Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex, PDB code: 4xry:
Jump to Fluorine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Fluorine binding site 1 out
of 8 in 4xry
Go back to
Fluorine Binding Sites List in 4xry
Fluorine binding site 1 out
of 8 in the Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F602
b:89.7
occ:1.00
|
F1
|
A:SI5602
|
0.0
|
89.7
|
1.0
|
C6
|
A:SI5602
|
1.4
|
86.1
|
1.0
|
C5
|
A:SI5602
|
2.3
|
81.4
|
1.0
|
C1
|
A:SI5602
|
2.4
|
87.2
|
1.0
|
C11
|
A:SI5602
|
2.9
|
88.4
|
1.0
|
C7
|
A:SI5602
|
2.9
|
89.2
|
1.0
|
C12
|
A:SI5602
|
3.2
|
81.7
|
1.0
|
CB
|
A:SER304
|
3.4
|
48.0
|
1.0
|
C4
|
A:SI5602
|
3.6
|
79.4
|
1.0
|
C2
|
A:SI5602
|
3.6
|
77.8
|
1.0
|
CD1
|
A:LEU213
|
3.9
|
76.3
|
1.0
|
OG
|
A:SER304
|
4.0
|
59.8
|
1.0
|
O1
|
A:SI5602
|
4.0
|
83.1
|
1.0
|
C8
|
A:SI5602
|
4.0
|
76.3
|
1.0
|
C3
|
A:SI5602
|
4.1
|
81.1
|
1.0
|
O
|
A:ALA209
|
4.1
|
66.0
|
1.0
|
CB
|
A:LEU213
|
4.2
|
69.0
|
1.0
|
C13
|
A:SI5602
|
4.3
|
72.6
|
1.0
|
C9
|
A:SI5602
|
4.3
|
73.4
|
1.0
|
N1
|
A:SI5602
|
4.3
|
83.9
|
1.0
|
CA
|
A:SER304
|
4.4
|
44.9
|
1.0
|
O
|
A:SER304
|
4.4
|
71.5
|
1.0
|
C
|
A:SER304
|
4.4
|
63.6
|
1.0
|
CG
|
A:LEU213
|
4.5
|
73.5
|
1.0
|
CA
|
A:LEU213
|
4.6
|
76.3
|
1.0
|
CG1
|
A:VAL308
|
4.6
|
45.0
|
1.0
|
F2
|
A:SI5602
|
4.7
|
69.3
|
1.0
|
N
|
A:LEU213
|
4.8
|
76.7
|
1.0
|
|
Fluorine binding site 2 out
of 8 in 4xry
Go back to
Fluorine Binding Sites List in 4xry
Fluorine binding site 2 out
of 8 in the Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F602
b:69.3
occ:1.00
|
F2
|
A:SI5602
|
0.0
|
69.3
|
1.0
|
C4
|
A:SI5602
|
1.4
|
79.4
|
1.0
|
C3
|
A:SI5602
|
2.3
|
81.1
|
1.0
|
C5
|
A:SI5602
|
2.3
|
81.4
|
1.0
|
OE1
|
A:GLN244
|
3.5
|
85.7
|
1.0
|
C6
|
A:SI5602
|
3.6
|
86.1
|
1.0
|
C2
|
A:SI5602
|
3.6
|
77.8
|
1.0
|
CA
|
A:GLY212
|
3.8
|
66.0
|
1.0
|
CD2
|
A:PHE247
|
3.8
|
36.5
|
1.0
|
CD
|
A:GLN244
|
3.9
|
72.8
|
1.0
|
CG
|
A:PHE247
|
4.0
|
40.4
|
1.0
|
O
|
A:ALA209
|
4.1
|
66.0
|
1.0
|
C1
|
A:SI5602
|
4.1
|
87.2
|
1.0
|
CB
|
A:PHE247
|
4.1
|
44.2
|
1.0
|
C
|
A:GLY212
|
4.2
|
80.6
|
1.0
|
CA
|
A:GLN244
|
4.3
|
61.3
|
1.0
|
CA
|
A:ALA209
|
4.3
|
57.4
|
1.0
|
O
|
A:LEU208
|
4.4
|
58.4
|
1.0
|
NE2
|
A:GLN244
|
4.4
|
63.5
|
1.0
|
CE2
|
A:PHE247
|
4.4
|
41.9
|
1.0
|
N
|
A:LEU213
|
4.6
|
76.7
|
1.0
|
N
|
A:GLY212
|
4.6
|
71.8
|
1.0
|
C
|
A:ALA209
|
4.6
|
67.1
|
1.0
|
CG
|
A:GLN244
|
4.6
|
65.8
|
1.0
|
F1
|
A:SI5602
|
4.7
|
89.7
|
1.0
|
CB
|
A:GLN244
|
4.7
|
65.3
|
1.0
|
O
|
A:PHE243
|
4.7
|
60.5
|
1.0
|
O
|
A:GLY212
|
4.8
|
82.7
|
1.0
|
CD1
|
A:PHE247
|
4.8
|
49.1
|
1.0
|
N
|
A:GLN244
|
4.9
|
62.4
|
1.0
|
|
Fluorine binding site 3 out
of 8 in 4xry
Go back to
Fluorine Binding Sites List in 4xry
Fluorine binding site 3 out
of 8 in the Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F602
b:86.8
occ:1.00
|
F1
|
B:SI5602
|
0.0
|
86.8
|
1.0
|
C6
|
B:SI5602
|
1.4
|
78.4
|
1.0
|
C5
|
B:SI5602
|
2.3
|
67.1
|
1.0
|
C1
|
B:SI5602
|
2.4
|
76.5
|
1.0
|
C11
|
B:SI5602
|
2.9
|
77.0
|
1.0
|
C7
|
B:SI5602
|
3.0
|
80.1
|
1.0
|
CB
|
B:SER304
|
3.1
|
52.2
|
1.0
|
C12
|
B:SI5602
|
3.2
|
77.1
|
1.0
|
C4
|
B:SI5602
|
3.6
|
78.5
|
1.0
|
C2
|
B:SI5602
|
3.6
|
66.1
|
1.0
|
OG
|
B:SER304
|
3.9
|
60.5
|
1.0
|
C8
|
B:SI5602
|
4.0
|
74.2
|
1.0
|
O1
|
B:SI5602
|
4.0
|
76.1
|
1.0
|
CB
|
B:LEU213
|
4.1
|
63.3
|
1.0
|
O
|
B:SER304
|
4.1
|
80.0
|
1.0
|
C3
|
B:SI5602
|
4.1
|
74.6
|
1.0
|
C
|
B:SER304
|
4.1
|
70.8
|
1.0
|
CA
|
B:SER304
|
4.1
|
46.5
|
1.0
|
O
|
B:ALA209
|
4.1
|
63.3
|
1.0
|
C13
|
B:SI5602
|
4.2
|
67.1
|
1.0
|
C9
|
B:SI5602
|
4.2
|
71.6
|
1.0
|
N1
|
B:SI5602
|
4.3
|
71.7
|
1.0
|
CG1
|
B:VAL308
|
4.5
|
57.6
|
1.0
|
CA
|
B:LEU213
|
4.5
|
70.0
|
1.0
|
CD1
|
B:LEU213
|
4.6
|
78.2
|
1.0
|
F2
|
B:SI5602
|
4.7
|
70.8
|
1.0
|
N
|
B:LEU213
|
4.7
|
73.1
|
1.0
|
N
|
B:ALA305
|
4.7
|
64.5
|
1.0
|
CG
|
B:LEU213
|
4.8
|
73.7
|
1.0
|
|
Fluorine binding site 4 out
of 8 in 4xry
Go back to
Fluorine Binding Sites List in 4xry
Fluorine binding site 4 out
of 8 in the Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F602
b:70.8
occ:1.00
|
F2
|
B:SI5602
|
0.0
|
70.8
|
1.0
|
C4
|
B:SI5602
|
1.4
|
78.5
|
1.0
|
C3
|
B:SI5602
|
2.3
|
74.6
|
1.0
|
C5
|
B:SI5602
|
2.3
|
67.1
|
1.0
|
CA
|
B:GLY212
|
3.5
|
69.9
|
1.0
|
C6
|
B:SI5602
|
3.6
|
78.4
|
1.0
|
C2
|
B:SI5602
|
3.6
|
66.1
|
1.0
|
CD2
|
B:PHE247
|
3.7
|
38.8
|
1.0
|
CG
|
B:GLN244
|
3.8
|
65.3
|
1.0
|
C
|
B:GLY212
|
3.8
|
74.9
|
1.0
|
CG
|
B:PHE247
|
4.0
|
38.7
|
1.0
|
O
|
B:ALA209
|
4.1
|
63.3
|
1.0
|
C1
|
B:SI5602
|
4.1
|
76.5
|
1.0
|
CA
|
B:GLN244
|
4.1
|
59.6
|
1.0
|
CB
|
B:PHE247
|
4.2
|
43.7
|
1.0
|
CA
|
B:ALA209
|
4.2
|
49.1
|
1.0
|
CB
|
B:GLN244
|
4.3
|
64.9
|
1.0
|
O
|
B:GLY212
|
4.3
|
74.5
|
1.0
|
CE2
|
B:PHE247
|
4.3
|
43.6
|
1.0
|
N
|
B:LEU213
|
4.3
|
73.1
|
1.0
|
CD
|
B:GLN244
|
4.3
|
69.5
|
1.0
|
O
|
B:LEU208
|
4.4
|
59.6
|
1.0
|
N
|
B:GLY212
|
4.4
|
66.1
|
1.0
|
C
|
B:ALA209
|
4.6
|
61.7
|
1.0
|
F1
|
B:SI5602
|
4.7
|
86.8
|
1.0
|
NE2
|
B:GLN244
|
4.7
|
69.9
|
1.0
|
CD1
|
B:PHE247
|
4.8
|
38.1
|
1.0
|
OE1
|
B:GLN244
|
4.9
|
74.8
|
1.0
|
O
|
B:GLN244
|
4.9
|
52.7
|
1.0
|
N
|
B:GLN244
|
5.0
|
54.6
|
1.0
|
|
Fluorine binding site 5 out
of 8 in 4xry
Go back to
Fluorine Binding Sites List in 4xry
Fluorine binding site 5 out
of 8 in the Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F602
b:71.4
occ:1.00
|
F1
|
C:SI5602
|
0.0
|
71.4
|
1.0
|
C6
|
C:SI5602
|
1.4
|
76.0
|
1.0
|
C5
|
C:SI5602
|
2.3
|
73.3
|
1.0
|
C1
|
C:SI5602
|
2.4
|
77.2
|
1.0
|
OG
|
C:SER304
|
2.5
|
82.9
|
1.0
|
C7
|
C:SI5602
|
2.9
|
83.7
|
1.0
|
C11
|
C:SI5602
|
2.9
|
82.6
|
1.0
|
C12
|
C:SI5602
|
3.2
|
85.3
|
1.0
|
C4
|
C:SI5602
|
3.6
|
72.5
|
1.0
|
C2
|
C:SI5602
|
3.6
|
72.9
|
1.0
|
CD1
|
C:LEU213
|
3.8
|
82.2
|
1.0
|
CB
|
C:SER304
|
3.8
|
44.5
|
1.0
|
O
|
C:ALA209
|
3.9
|
64.7
|
1.0
|
CB
|
C:LEU213
|
4.0
|
63.1
|
1.0
|
O1
|
C:SI5602
|
4.0
|
75.5
|
1.0
|
C8
|
C:SI5602
|
4.0
|
70.3
|
1.0
|
C3
|
C:SI5602
|
4.1
|
75.7
|
1.0
|
C13
|
C:SI5602
|
4.2
|
77.3
|
1.0
|
C9
|
C:SI5602
|
4.3
|
74.2
|
1.0
|
N1
|
C:SI5602
|
4.3
|
77.9
|
1.0
|
CG
|
C:LEU213
|
4.3
|
83.7
|
1.0
|
CA
|
C:LEU213
|
4.4
|
69.2
|
1.0
|
CG1
|
C:VAL308
|
4.5
|
56.5
|
1.0
|
N
|
C:LEU213
|
4.6
|
74.0
|
1.0
|
F2
|
C:SI5602
|
4.7
|
65.7
|
1.0
|
C
|
C:SER304
|
4.8
|
60.5
|
1.0
|
CA
|
C:SER304
|
4.8
|
47.9
|
1.0
|
O
|
C:SER304
|
4.8
|
61.9
|
1.0
|
C
|
C:ALA209
|
4.9
|
65.0
|
1.0
|
|
Fluorine binding site 6 out
of 8 in 4xry
Go back to
Fluorine Binding Sites List in 4xry
Fluorine binding site 6 out
of 8 in the Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F602
b:65.7
occ:1.00
|
F2
|
C:SI5602
|
0.0
|
65.7
|
1.0
|
C4
|
C:SI5602
|
1.4
|
72.5
|
1.0
|
C5
|
C:SI5602
|
2.3
|
73.3
|
1.0
|
C3
|
C:SI5602
|
2.3
|
75.7
|
1.0
|
CA
|
C:GLY212
|
3.5
|
67.9
|
1.0
|
CG
|
C:GLN244
|
3.5
|
63.6
|
1.0
|
C6
|
C:SI5602
|
3.6
|
76.0
|
1.0
|
C2
|
C:SI5602
|
3.6
|
72.9
|
1.0
|
C
|
C:GLY212
|
3.9
|
68.2
|
1.0
|
CA
|
C:GLN244
|
4.0
|
59.2
|
1.0
|
CD2
|
C:PHE247
|
4.1
|
39.1
|
1.0
|
CB
|
C:GLN244
|
4.1
|
66.3
|
1.0
|
C1
|
C:SI5602
|
4.1
|
77.2
|
1.0
|
CB
|
C:PHE247
|
4.1
|
46.1
|
1.0
|
O
|
C:ALA209
|
4.1
|
64.7
|
1.0
|
O
|
C:LEU208
|
4.2
|
68.1
|
1.0
|
CG
|
C:PHE247
|
4.2
|
45.3
|
1.0
|
O
|
C:GLY212
|
4.3
|
73.0
|
1.0
|
CD
|
C:GLN244
|
4.3
|
72.2
|
1.0
|
N
|
C:LEU213
|
4.3
|
74.0
|
1.0
|
N
|
C:GLY212
|
4.4
|
71.7
|
1.0
|
CA
|
C:ALA209
|
4.4
|
52.2
|
1.0
|
NE2
|
C:GLN244
|
4.6
|
71.7
|
1.0
|
F1
|
C:SI5602
|
4.7
|
71.4
|
1.0
|
N
|
C:GLN244
|
4.7
|
53.4
|
1.0
|
C
|
C:ALA209
|
4.7
|
65.0
|
1.0
|
CE2
|
C:PHE247
|
4.8
|
48.8
|
1.0
|
O
|
C:PHE243
|
4.8
|
60.7
|
1.0
|
CD1
|
C:PHE247
|
4.9
|
46.4
|
1.0
|
|
Fluorine binding site 7 out
of 8 in 4xry
Go back to
Fluorine Binding Sites List in 4xry
Fluorine binding site 7 out
of 8 in the Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:F602
b:85.2
occ:1.00
|
F1
|
D:SI5602
|
0.0
|
85.2
|
1.0
|
C6
|
D:SI5602
|
1.4
|
81.4
|
1.0
|
C5
|
D:SI5602
|
2.3
|
75.7
|
1.0
|
C1
|
D:SI5602
|
2.4
|
85.6
|
1.0
|
C11
|
D:SI5602
|
2.9
|
84.2
|
1.0
|
C7
|
D:SI5602
|
3.0
|
84.0
|
1.0
|
CB
|
D:SER304
|
3.1
|
47.1
|
1.0
|
C12
|
D:SI5602
|
3.2
|
80.6
|
1.0
|
OG
|
D:SER304
|
3.5
|
52.6
|
1.0
|
C4
|
D:SI5602
|
3.6
|
73.4
|
1.0
|
C2
|
D:SI5602
|
3.6
|
74.8
|
1.0
|
CD1
|
D:LEU213
|
3.8
|
81.9
|
1.0
|
C8
|
D:SI5602
|
4.0
|
76.1
|
1.0
|
O1
|
D:SI5602
|
4.0
|
84.3
|
1.0
|
O
|
D:SER304
|
4.1
|
76.9
|
1.0
|
C3
|
D:SI5602
|
4.1
|
75.1
|
1.0
|
C
|
D:SER304
|
4.1
|
65.9
|
1.0
|
C13
|
D:SI5602
|
4.1
|
63.4
|
1.0
|
CA
|
D:SER304
|
4.1
|
44.4
|
1.0
|
C9
|
D:SI5602
|
4.2
|
75.4
|
1.0
|
CB
|
D:LEU213
|
4.2
|
65.9
|
1.0
|
O
|
D:ALA209
|
4.3
|
66.2
|
1.0
|
N1
|
D:SI5602
|
4.3
|
78.6
|
1.0
|
CG1
|
D:VAL308
|
4.6
|
61.3
|
1.0
|
CG
|
D:LEU213
|
4.6
|
76.2
|
1.0
|
CA
|
D:LEU213
|
4.7
|
72.3
|
1.0
|
F2
|
D:SI5602
|
4.7
|
69.0
|
1.0
|
N
|
D:ALA305
|
4.7
|
55.6
|
1.0
|
N
|
D:LEU213
|
4.9
|
73.9
|
1.0
|
|
Fluorine binding site 8 out
of 8 in 4xry
Go back to
Fluorine Binding Sites List in 4xry
Fluorine binding site 8 out
of 8 in the Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Human Cytochrome P450 2D6 BACE1 Inhibitor 5 Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:F602
b:69.0
occ:1.00
|
F2
|
D:SI5602
|
0.0
|
69.0
|
1.0
|
C4
|
D:SI5602
|
1.4
|
73.4
|
1.0
|
C3
|
D:SI5602
|
2.3
|
75.1
|
1.0
|
C5
|
D:SI5602
|
2.3
|
75.7
|
1.0
|
C6
|
D:SI5602
|
3.6
|
81.4
|
1.0
|
C2
|
D:SI5602
|
3.6
|
74.8
|
1.0
|
CA
|
D:GLY212
|
3.7
|
68.0
|
1.0
|
CG
|
D:GLN244
|
3.7
|
70.5
|
1.0
|
CD2
|
D:PHE247
|
3.7
|
40.4
|
1.0
|
C
|
D:GLY212
|
3.9
|
73.1
|
1.0
|
CA
|
D:GLN244
|
4.0
|
63.8
|
1.0
|
O
|
D:ALA209
|
4.0
|
66.2
|
1.0
|
CG
|
D:PHE247
|
4.0
|
41.3
|
1.0
|
C1
|
D:SI5602
|
4.1
|
85.6
|
1.0
|
CB
|
D:GLN244
|
4.2
|
69.9
|
1.0
|
O
|
D:GLY212
|
4.2
|
70.2
|
1.0
|
CB
|
D:PHE247
|
4.2
|
50.0
|
1.0
|
CE2
|
D:PHE247
|
4.3
|
44.9
|
1.0
|
CA
|
D:ALA209
|
4.4
|
57.9
|
1.0
|
N
|
D:LEU213
|
4.4
|
73.9
|
1.0
|
CD
|
D:GLN244
|
4.5
|
66.3
|
1.0
|
O
|
D:LEU208
|
4.5
|
57.0
|
1.0
|
N
|
D:GLY212
|
4.6
|
63.7
|
1.0
|
C
|
D:ALA209
|
4.7
|
68.6
|
1.0
|
F1
|
D:SI5602
|
4.7
|
85.2
|
1.0
|
CD1
|
D:PHE247
|
4.8
|
44.5
|
1.0
|
N
|
D:GLN244
|
4.8
|
57.4
|
1.0
|
O
|
D:GLN244
|
4.9
|
58.7
|
1.0
|
NE2
|
D:GLN244
|
4.9
|
65.6
|
1.0
|
C
|
D:GLN244
|
5.0
|
65.1
|
1.0
|
|
Reference:
M.A.Brodney,
E.M.Beck,
C.R.Butler,
G.Barreiro,
E.F.Johnson,
D.Riddell,
K.Parris,
C.E.Nolan,
Y.Fan,
K.Atchison,
C.Gonzales,
A.E.Robshaw,
S.D.Doran,
M.W.Bundesmann,
L.Buzon,
J.Dutra,
K.Henegar,
E.Lachapelle,
X.Hou,
B.N.Rogers,
J.Pandit,
R.Lira,
L.Martinez-Alsina,
P.Mikochik,
J.C.Murray,
K.Ogilvie,
L.Price,
S.M.Sakya,
A.Yu,
Y.Zhang,
B.T.O'neill.
Utilizing Structures of CYP2D6 and BACE1 Complexes to Reduce Risk of Drug-Drug Interactions with A Novel Series of Centrally Efficacious BACE1 Inhibitors. J.Med.Chem. V. 58 3223 2015.
ISSN: ISSN 0022-2623
PubMed: 25781223
DOI: 10.1021/ACS.JMEDCHEM.5B00191
Page generated: Thu Aug 1 06:44:38 2024
|