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Atomistry » Fluorine » PDB 4x7j-4xxs » 4xv3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4x7j-4xxs » 4xv3 » |
Fluorine in PDB 4xv3: B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX7922Enzymatic activity of B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX7922
All present enzymatic activity of B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX7922:
2.7.11.1; Protein crystallography data
The structure of B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX7922, PDB code: 4xv3
was solved by
Y.Zhang,
C.Zhang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX7922
(pdb code 4xv3). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX7922, PDB code: 4xv3: Fluorine binding site 1 out of 1 in 4xv3Go back to Fluorine Binding Sites List in 4xv3
Fluorine binding site 1 out
of 1 in the B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX7922
Mono view Stereo pair view
Reference:
C.Zhang,
W.Spevak,
Y.Zhang,
E.A.Burton,
Y.Ma,
G.Habets,
J.Zhang,
J.Lin,
T.Ewing,
B.Matusow,
G.Tsang,
A.Marimuthu,
H.Cho,
G.Wu,
W.Wang,
D.Fong,
H.Nguyen,
S.Shi,
P.Womack,
M.Nespi,
R.Shellooe,
H.Carias,
B.Powell,
E.Light,
L.Sanftner,
J.Walters,
J.Tsai,
B.L.West,
G.Visor,
H.Rezaei,
P.S.Lin,
K.Nolop,
P.N.Ibrahim,
P.Hirth,
G.Bollag.
Raf Inhibitors That Evade Paradoxical Mapk Pathway Activation. Nature V. 526 583 2015.
Page generated: Sun Dec 13 12:15:25 2020
ISSN: ESSN 1476-4687 PubMed: 26466569 DOI: 10.1038/NATURE14982 |
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