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Fluorine in PDB 4xyf: Crystal Structure of C-Met in Complex with (S)-5-(8-Fluoro-3-(1-(3-(2- Methoxyethoxy)Quinolin-6-Yl)Ethyl)-[1,2,4]Triazolo[4,3-A]Pyridin-6- Yl)-3-MethylisoxazoleEnzymatic activity of Crystal Structure of C-Met in Complex with (S)-5-(8-Fluoro-3-(1-(3-(2- Methoxyethoxy)Quinolin-6-Yl)Ethyl)-[1,2,4]Triazolo[4,3-A]Pyridin-6- Yl)-3-Methylisoxazole
All present enzymatic activity of Crystal Structure of C-Met in Complex with (S)-5-(8-Fluoro-3-(1-(3-(2- Methoxyethoxy)Quinolin-6-Yl)Ethyl)-[1,2,4]Triazolo[4,3-A]Pyridin-6- Yl)-3-Methylisoxazole:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of C-Met in Complex with (S)-5-(8-Fluoro-3-(1-(3-(2- Methoxyethoxy)Quinolin-6-Yl)Ethyl)-[1,2,4]Triazolo[4,3-A]Pyridin-6- Yl)-3-Methylisoxazole, PDB code: 4xyf
was solved by
D.A.Whittington,
A.M.Long,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of C-Met in Complex with (S)-5-(8-Fluoro-3-(1-(3-(2- Methoxyethoxy)Quinolin-6-Yl)Ethyl)-[1,2,4]Triazolo[4,3-A]Pyridin-6- Yl)-3-Methylisoxazole
(pdb code 4xyf). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of C-Met in Complex with (S)-5-(8-Fluoro-3-(1-(3-(2- Methoxyethoxy)Quinolin-6-Yl)Ethyl)-[1,2,4]Triazolo[4,3-A]Pyridin-6- Yl)-3-Methylisoxazole, PDB code: 4xyf: Fluorine binding site 1 out of 1 in 4xyfGo back to Fluorine Binding Sites List in 4xyf
Fluorine binding site 1 out
of 1 in the Crystal Structure of C-Met in Complex with (S)-5-(8-Fluoro-3-(1-(3-(2- Methoxyethoxy)Quinolin-6-Yl)Ethyl)-[1,2,4]Triazolo[4,3-A]Pyridin-6- Yl)-3-Methylisoxazole
Mono view Stereo pair view
Reference:
E.A.Peterson,
Y.Teffera,
B.Albecht,
D.Bauer,
S.Bellon,
A.A.Boezio,
C.Boezio,
M.Broome,
D.Choquette,
K.W.Copeland,
I.Dussault,
R.T.Lewis,
J.Lin,
J.Lohman,
J.Liu,
M.Potashman,
K.Rex,
R.Shimanovich,
D.A.Whittington,
K.Vaida,
J.C.Harmange.
Discovery of Potent and Selective 8-Fluorotriazolopyridine C-Met Inhibitors. J.Med.Chem. 2015.
Page generated: Sun Dec 13 12:15:32 2020
ISSN: ISSN 0022-2623 PubMed: 25699405 DOI: 10.1021/JM501913A |
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