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Atomistry » Fluorine » PDB 4ymq-4zg9 » 4ypq | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4ymq-4zg9 » 4ypq » |
Fluorine in PDB 4ypq: Crystal Structure of the Ror(Gamma)T Ligand Binding Domain in Complex with 4-(1-(2-Chloro-6-(Trifluoromethyl)Benzoyl)-1H-Indazol-3-Yl) Benzoic AcidProtein crystallography data
The structure of Crystal Structure of the Ror(Gamma)T Ligand Binding Domain in Complex with 4-(1-(2-Chloro-6-(Trifluoromethyl)Benzoyl)-1H-Indazol-3-Yl) Benzoic Acid, PDB code: 4ypq
was solved by
S.Leysen,
M.Scheepstra,
G.C.Van Almen,
C.Ottmann,
L.Brunsveld,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4ypq:
The structure of Crystal Structure of the Ror(Gamma)T Ligand Binding Domain in Complex with 4-(1-(2-Chloro-6-(Trifluoromethyl)Benzoyl)-1H-Indazol-3-Yl) Benzoic Acid also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Ror(Gamma)T Ligand Binding Domain in Complex with 4-(1-(2-Chloro-6-(Trifluoromethyl)Benzoyl)-1H-Indazol-3-Yl) Benzoic Acid
(pdb code 4ypq). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of the Ror(Gamma)T Ligand Binding Domain in Complex with 4-(1-(2-Chloro-6-(Trifluoromethyl)Benzoyl)-1H-Indazol-3-Yl) Benzoic Acid, PDB code: 4ypq: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 4ypqGo back to Fluorine Binding Sites List in 4ypq
Fluorine binding site 1 out
of 3 in the Crystal Structure of the Ror(Gamma)T Ligand Binding Domain in Complex with 4-(1-(2-Chloro-6-(Trifluoromethyl)Benzoyl)-1H-Indazol-3-Yl) Benzoic Acid
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 4ypqGo back to Fluorine Binding Sites List in 4ypq
Fluorine binding site 2 out
of 3 in the Crystal Structure of the Ror(Gamma)T Ligand Binding Domain in Complex with 4-(1-(2-Chloro-6-(Trifluoromethyl)Benzoyl)-1H-Indazol-3-Yl) Benzoic Acid
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 4ypqGo back to Fluorine Binding Sites List in 4ypq
Fluorine binding site 3 out
of 3 in the Crystal Structure of the Ror(Gamma)T Ligand Binding Domain in Complex with 4-(1-(2-Chloro-6-(Trifluoromethyl)Benzoyl)-1H-Indazol-3-Yl) Benzoic Acid
Mono view Stereo pair view
Reference:
M.Scheepstra,
S.Leysen,
G.C.Van Almen,
J.R.Miller,
J.Piesvaux,
V.Kutilek,
H.Van Eenennaam,
H.Zhang,
K.Barr,
S.Nagpal,
S.M.Soisson,
M.Kornienko,
K.Wiley,
N.Elsen,
S.Sharma,
C.C.Correll,
B.W.Trotter,
M.Van Der Stelt,
A.Oubrie,
C.Ottmann,
G.Parthasarathy,
L.Brunsveld.
Identification of An Allosteric Binding Site For Ror Gamma T Inhibition. Nat Commun V. 6 8833 2015.
Page generated: Sun Dec 13 12:16:11 2020
ISSN: ESSN 2041-1723 PubMed: 26640126 DOI: 10.1038/NCOMMS9833 |
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