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Atomistry » Fluorine » PDB 4ymq-4zg9 » 4yt7 » |
Fluorine in PDB 4yt7: Factor Viia in Complex with the Inhibitor 2-(2-{(R)-[(4- Carbamimidoylphenyl)Amino][5-Ethoxy-2-Fluoro-3-(Propan-2-Yloxy) Phenyl]Methyl}-1H-Imidazol-4-Yl)BenzamideEnzymatic activity of Factor Viia in Complex with the Inhibitor 2-(2-{(R)-[(4- Carbamimidoylphenyl)Amino][5-Ethoxy-2-Fluoro-3-(Propan-2-Yloxy) Phenyl]Methyl}-1H-Imidazol-4-Yl)Benzamide
All present enzymatic activity of Factor Viia in Complex with the Inhibitor 2-(2-{(R)-[(4- Carbamimidoylphenyl)Amino][5-Ethoxy-2-Fluoro-3-(Propan-2-Yloxy) Phenyl]Methyl}-1H-Imidazol-4-Yl)Benzamide:
3.4.21.21; Protein crystallography data
The structure of Factor Viia in Complex with the Inhibitor 2-(2-{(R)-[(4- Carbamimidoylphenyl)Amino][5-Ethoxy-2-Fluoro-3-(Propan-2-Yloxy) Phenyl]Methyl}-1H-Imidazol-4-Yl)Benzamide, PDB code: 4yt7
was solved by
A.Wei,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4yt7:
The structure of Factor Viia in Complex with the Inhibitor 2-(2-{(R)-[(4- Carbamimidoylphenyl)Amino][5-Ethoxy-2-Fluoro-3-(Propan-2-Yloxy) Phenyl]Methyl}-1H-Imidazol-4-Yl)Benzamide also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Factor Viia in Complex with the Inhibitor 2-(2-{(R)-[(4- Carbamimidoylphenyl)Amino][5-Ethoxy-2-Fluoro-3-(Propan-2-Yloxy) Phenyl]Methyl}-1H-Imidazol-4-Yl)Benzamide
(pdb code 4yt7). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Factor Viia in Complex with the Inhibitor 2-(2-{(R)-[(4- Carbamimidoylphenyl)Amino][5-Ethoxy-2-Fluoro-3-(Propan-2-Yloxy) Phenyl]Methyl}-1H-Imidazol-4-Yl)Benzamide, PDB code: 4yt7: Fluorine binding site 1 out of 1 in 4yt7Go back to Fluorine Binding Sites List in 4yt7
Fluorine binding site 1 out
of 1 in the Factor Viia in Complex with the Inhibitor 2-(2-{(R)-[(4- Carbamimidoylphenyl)Amino][5-Ethoxy-2-Fluoro-3-(Propan-2-Yloxy) Phenyl]Methyl}-1H-Imidazol-4-Yl)Benzamide
Mono view Stereo pair view
Reference:
P.W.Glunz,
X.Cheng,
D.L.Cheney,
C.A.Weigelt,
A.Wei,
J.M.Luettgen,
P.C.Wong,
R.R.Wexler,
E.S.Priestley.
Design and Synthesis of Potent, Selective Phenylimidazole-Based Fviia Inhibitors. Bioorg.Med.Chem.Lett. V. 25 2169 2015.
Page generated: Sun Dec 13 12:16:14 2020
ISSN: ESSN 1464-3405 PubMed: 25881820 DOI: 10.1016/J.BMCL.2015.03.062 |
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