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Fluorine in PDB 4zga: Structural Basis For Inhibition of Human Autotaxin By Four Novel Compounds
Enzymatic activity of Structural Basis For Inhibition of Human Autotaxin By Four Novel Compounds
All present enzymatic activity of Structural Basis For Inhibition of Human Autotaxin By Four Novel Compounds:
3.1.4.39;
3.1.4.39;
Protein crystallography data
The structure of Structural Basis For Inhibition of Human Autotaxin By Four Novel Compounds, PDB code: 4zga
was solved by
A.J.Stein,
G.Bain,
J.H.Hutchinson,
J.F.Evans,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 49.74 / 2.60 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 53.672, 64.001, 70.505, 99.44, 108.39, 98.61 |
| R / Rfree (%) | 20.8 / 27.4 |
Other elements in 4zga:
The structure of Structural Basis For Inhibition of Human Autotaxin By Four Novel Compounds also contains other interesting chemical elements:
| Calcium | (Ca) | 2 atoms |
| Zinc | (Zn) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structural Basis For Inhibition of Human Autotaxin By Four Novel Compounds
(pdb code 4zga). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structural Basis For Inhibition of Human Autotaxin By Four Novel Compounds, PDB code: 4zga:
In total only one binding site of Fluorine was determined in the Structural Basis For Inhibition of Human Autotaxin By Four Novel Compounds, PDB code: 4zga:
Fluorine binding site 1 out of 1 in 4zga
Go back to
Fluorine Binding Sites List in 4zga
Fluorine binding site 1 out
of 1 in the Structural Basis For Inhibition of Human Autotaxin By Four Novel Compounds
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structural Basis For Inhibition of Human Autotaxin By Four Novel Compounds within 5.0Å range:
|
Reference:
A.J.Stein,
G.Bain,
P.Prodanovich,
A.M.Santini,
J.Darlington,
N.M.Stelzer,
R.S.Sidhu,
J.Schaub,
L.Goulet,
D.Lonergan,
I.Calderon,
J.F.Evans,
J.H.Hutchinson.
Structural Basis For Inhibition of Human Autotaxin By Four Potent Compounds with Distinct Modes of Binding. Mol.Pharmacol. V. 88 982 2015.
ISSN: ESSN 1521-0111
PubMed: 26371182
DOI: 10.1124/MOL.115.100404
Page generated: Sun Dec 13 12:16:46 2020
ISSN: ESSN 1521-0111
PubMed: 26371182
DOI: 10.1124/MOL.115.100404
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