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Fluorine in PDB 4zh3: Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br
Enzymatic activity of Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br
All present enzymatic activity of Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br:
2.7.7.6;
2.7.7.6;
Protein crystallography data
The structure of Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br, PDB code: 4zh3
was solved by
Y.Feng,
R.H.Ebright,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 49.75 / 4.08 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 186.339, 205.790, 307.630, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 23.8 / 26.7 |
Other elements in 4zh3:
The structure of Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br also contains other interesting chemical elements:
| Magnesium | (Mg) | 2 atoms |
| Zinc | (Zn) | 4 atoms |
| Bromine | (Br) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br
(pdb code 4zh3). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br, PDB code: 4zh3:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Fluorine where determined in the Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br, PDB code: 4zh3:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Fluorine binding site 1 out of 8 in 4zh3
Go back to
Fluorine Binding Sites List in 4zh3
Fluorine binding site 1 out
of 8 in the Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br within 5.0Å range:
|
Fluorine binding site 2 out of 8 in 4zh3
Go back to
Fluorine Binding Sites List in 4zh3
Fluorine binding site 2 out
of 8 in the Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br within 5.0Å range:
|
Fluorine binding site 3 out of 8 in 4zh3
Go back to
Fluorine Binding Sites List in 4zh3
Fluorine binding site 3 out
of 8 in the Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br within 5.0Å range:
|
Fluorine binding site 4 out of 8 in 4zh3
Go back to
Fluorine Binding Sites List in 4zh3
Fluorine binding site 4 out
of 8 in the Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br within 5.0Å range:
|
Fluorine binding site 5 out of 8 in 4zh3
Go back to
Fluorine Binding Sites List in 4zh3
Fluorine binding site 5 out
of 8 in the Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br within 5.0Å range:
|
Fluorine binding site 6 out of 8 in 4zh3
Go back to
Fluorine Binding Sites List in 4zh3
Fluorine binding site 6 out
of 8 in the Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br within 5.0Å range:
|
Fluorine binding site 7 out of 8 in 4zh3
Go back to
Fluorine Binding Sites List in 4zh3
Fluorine binding site 7 out
of 8 in the Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br within 5.0Å range:
|
Fluorine binding site 8 out of 8 in 4zh3
Go back to
Fluorine Binding Sites List in 4zh3
Fluorine binding site 8 out
of 8 in the Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Crystal Structure of Escherichia Coli Rna Polymerase in Complex with CBRH16-Br within 5.0Å range:
|
Reference:
Y.Feng,
D.Degen,
X.Wang,
M.Gigliotti,
S.Liu,
Y.Zhang,
D.Das,
T.Michalchuk,
Y.W.Ebright,
M.Talaue,
N.Connell,
R.H.Ebright.
Structural Basis of Transcription Inhibition By Cbr Hydroxamidines and Cbr Pyrazoles. Structure V. 23 1470 2015.
ISSN: ISSN 0969-2126
PubMed: 26190576
DOI: 10.1016/J.STR.2015.06.009
Page generated: Thu Aug 1 07:18:24 2024
ISSN: ISSN 0969-2126
PubMed: 26190576
DOI: 10.1016/J.STR.2015.06.009
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