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Atomistry » Fluorine » PDB 4zga-4zzi » 4zk5 » |
Fluorine in PDB 4zk5: MAP4K4 in Complex with Inhibitor Gne-495Enzymatic activity of MAP4K4 in Complex with Inhibitor Gne-495
All present enzymatic activity of MAP4K4 in Complex with Inhibitor Gne-495:
2.7.11.1; Protein crystallography data
The structure of MAP4K4 in Complex with Inhibitor Gne-495, PDB code: 4zk5
was solved by
S.F.Harris,
P.Wu,
M.Coons,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4zk5:
The structure of MAP4K4 in Complex with Inhibitor Gne-495 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the MAP4K4 in Complex with Inhibitor Gne-495
(pdb code 4zk5). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the MAP4K4 in Complex with Inhibitor Gne-495, PDB code: 4zk5: Fluorine binding site 1 out of 1 in 4zk5Go back to Fluorine Binding Sites List in 4zk5
Fluorine binding site 1 out
of 1 in the MAP4K4 in Complex with Inhibitor Gne-495
Mono view Stereo pair view
Reference:
C.O.Ndubaku,
T.D.Crawford,
H.Chen,
J.W.Boggs,
J.Drobnick,
S.F.Harris,
R.Jesudason,
E.Mcnamara,
J.Nonomiya,
A.Sambrone,
S.Schmidt,
T.Smyczek,
P.Vitorino,
L.Wang,
P.Wu,
S.Yeung,
J.Chen,
K.Chen,
C.Z.Ding,
T.Wang,
Z.Xu,
S.E.Gould,
L.J.Murray,
W.Ye.
Structure-Based Design of Gne-495, A Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. Acs Med.Chem.Lett. V. 6 913 2015.
Page generated: Thu Aug 1 07:19:07 2024
ISSN: ISSN 1948-5875 PubMed: 26288693 DOI: 10.1021/ACSMEDCHEMLETT.5B00174 |
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