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Fluorine in PDB 4zl1: Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with 18X at 1.86 A Resolution

Enzymatic activity of Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with 18X at 1.86 A Resolution

All present enzymatic activity of Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with 18X at 1.86 A Resolution:
1.3.5.2;

Protein crystallography data

The structure of Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with 18X at 1.86 A Resolution, PDB code: 4zl1 was solved by J.Huang, D.Wu, P.Ouyang, W.Lu, J.Pu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.04 / 1.86
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 91.319, 91.319, 122.824, 90.00, 90.00, 120.00
R / Rfree (%) 16 / 17.9

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with 18X at 1.86 A Resolution (pdb code 4zl1). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with 18X at 1.86 A Resolution, PDB code: 4zl1:

Fluorine binding site 1 out of 1 in 4zl1

Go back to Fluorine Binding Sites List in 4zl1
Fluorine binding site 1 out of 1 in the Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with 18X at 1.86 A Resolution


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with 18X at 1.86 A Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F403

b:43.2
occ:1.00
 F25 A:18X403 0.0 43.2 1.0
C18 A:18X403 1.4 33.8 1.0
C17 A:18X403 2.4 34.2 1.0
C13 A:18X403 2.5 36.2 1.0
N9 A:18X403 2.8 34.3 1.0
C8 A:18X403 3.2 38.1 1.0
C3 A:18X403 3.3 37.9 1.0
C1 A:18X403 3.3 35.4 1.0
SD A:MET43 3.5 28.3 1.0
C16 A:18X403 3.6 27.4 1.0
C10 A:18X403 3.6 38.9 1.0
CD2 A:LEU42 3.6 43.7 1.0
N4 A:18X403 3.7 31.0 1.0
CD1 A:LEU46 3.7 45.6 1.0
C14 A:18X403 3.8 32.9 1.0
CE2 A:TYR38 3.8 36.1 1.0
O26 A:18X403 4.0 38.9 1.0
CG A:LEU42 4.1 42.2 1.0
C15 A:18X403 4.1 29.8 1.0
CD2 A:TYR38 4.1 34.3 1.0
S12 A:18X403 4.4 39.5 1.0
C2 A:18X403 4.4 43.8 1.0
CD A:PRO364 4.4 23.1 1.0
CE A:MET43 4.6 30.4 1.0
C11 A:18X403 4.7 35.0 1.0
C19 A:18X403 4.8 32.0 1.0
O5 A:18X403 4.9 40.9 1.0
CG A:PRO364 5.0 25.3 1.0
CD1 A:LEU42 5.0 45.0 1.0

Reference:

J.Huang, D.Wu, P.Ouyang, W.Lu, J.Pu. Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with 18XYW at 1.86 A Resolution To Be Published.
Page generated: Thu Aug 1 07:19:12 2024

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