Atomistry » Fluorine » PDB 4zga-4zzi » 4zmg
Atomistry »
  Fluorine »
    PDB 4zga-4zzi »
      4zmg »

Fluorine in PDB 4zmg: Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with DH03A338

Enzymatic activity of Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with DH03A338

All present enzymatic activity of Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with DH03A338:
1.3.5.2;

Protein crystallography data

The structure of Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with DH03A338, PDB code: 4zmg was solved by X.L.Ren, J.S.Zhu, L.L.Zhu, H.L.Li, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.51 / 1.90
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 91.020, 91.020, 122.790, 90.00, 90.00, 120.00
R / Rfree (%) 17.6 / 19.8

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with DH03A338 (pdb code 4zmg). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with DH03A338, PDB code: 4zmg:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in 4zmg

Go back to Fluorine Binding Sites List in 4zmg
Fluorine binding site 1 out of 2 in the Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with DH03A338


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with DH03A338 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F403

b:17.5
occ:1.00
F22 A:4R5403 0.0 17.5 1.0
C10 A:4R5403 1.3 16.7 1.0
C9 A:4R5403 2.3 16.2 1.0
C11 A:4R5403 2.4 16.4 1.0
N8 A:4R5403 2.8 15.8 1.0
O21 A:4R5403 2.8 14.1 1.0
C7 A:4R5403 3.0 15.5 1.0
O A:LEU359 3.4 14.3 1.0
CA A:THR360 3.5 14.3 1.0
C A:LEU359 3.6 13.8 1.0
C14 A:4R5403 3.6 17.2 1.0
CG A:LEU359 3.6 16.3 1.0
C12 A:4R5403 3.6 16.6 1.0
N A:THR360 3.7 13.6 1.0
CG2 A:THR360 3.8 14.1 1.0
CD2 A:LEU359 4.0 17.0 1.0
CE1 A:PHE98 4.0 15.1 1.0
N6 A:4R5403 4.1 15.8 1.0
C13 A:4R5403 4.1 16.6 1.0
CB A:LEU359 4.1 14.2 1.0
CB A:THR360 4.1 14.6 1.0
CB A:ALA59 4.1 15.1 1.0
CA A:LEU359 4.5 13.6 1.0
CE A:MET43 4.6 19.3 1.0
F24 A:4R5403 4.7 17.3 1.0
C A:THR360 4.7 15.5 1.0
C2 A:4R5403 4.7 16.1 1.0
CD1 A:PHE98 4.8 14.7 1.0
CD1 A:LEU359 4.8 16.7 1.0
CZ A:PHE98 4.8 15.1 1.0
C3 A:4R5403 4.8 15.7 1.0
C15 A:4R5403 4.9 17.1 1.0

Fluorine binding site 2 out of 2 in 4zmg

Go back to Fluorine Binding Sites List in 4zmg
Fluorine binding site 2 out of 2 in the Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with DH03A338


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with DH03A338 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F403

b:17.3
occ:1.00
F24 A:4R5403 0.0 17.3 1.0
C14 A:4R5403 1.3 17.2 1.0
C9 A:4R5403 2.4 16.2 1.0
C13 A:4R5403 2.4 16.6 1.0
N8 A:4R5403 2.7 15.8 1.0
O A:HOH579 3.5 21.9 1.0
C10 A:4R5403 3.6 16.7 1.0
CB A:ALA55 3.6 15.8 1.0
C12 A:4R5403 3.6 16.6 1.0
O A:ALA55 3.6 14.5 1.0
C7 A:4R5403 3.7 15.5 1.0
CE A:MET43 4.0 19.3 1.0
CA A:ALA55 4.0 15.3 1.0
C A:ALA55 4.0 14.5 1.0
CD1 A:LEU46 4.1 30.5 1.0
C11 A:4R5403 4.1 16.4 1.0
O21 A:4R5403 4.3 14.1 1.0
CB A:LEU46 4.4 28.3 1.0
CB A:ALA59 4.5 15.1 1.0
N6 A:4R5403 4.5 15.8 1.0
F22 A:4R5403 4.7 17.5 1.0
C15 A:4R5403 4.8 17.1 1.0
CG A:LEU46 4.9 30.6 1.0
SD A:MET43 5.0 20.6 1.0
N A:ALA59 5.0 16.0 1.0

Reference:

X.L.Ren, J.S.Zhu, L.L.Zhu, H.L.Li. Crystal Structure of Human Dihydroorotate Dehydrogenase (Dhodh) with DH03A338 To Be Published.
Page generated: Sun Dec 13 12:17:10 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy