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Fluorine in PDB 4zum: Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor
Protein crystallography data
The structure of Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor, PDB code: 4zum
was solved by
C.Decroos,
D.W.Christianson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 38.89 / 1.42 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 45.119, 121.351, 64.295, 90.00, 96.76, 90.00 |
| R / Rfree (%) | 13.3 / 15.3 |
Other elements in 4zum:
The structure of Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor also contains other interesting chemical elements:
| Potassium | (K) | 2 atoms |
| Zinc | (Zn) | 2 atoms |
| Sodium | (Na) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor
(pdb code 4zum). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor, PDB code: 4zum:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor, PDB code: 4zum:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 4zum
Go back to
Fluorine Binding Sites List in 4zum
Fluorine binding site 1 out
of 6 in the Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 4zum
Go back to
Fluorine Binding Sites List in 4zum
Fluorine binding site 2 out
of 6 in the Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 4zum
Go back to
Fluorine Binding Sites List in 4zum
Fluorine binding site 3 out
of 6 in the Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 4zum
Go back to
Fluorine Binding Sites List in 4zum
Fluorine binding site 4 out
of 6 in the Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 4zum
Go back to
Fluorine Binding Sites List in 4zum
Fluorine binding site 5 out
of 6 in the Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 4zum
Go back to
Fluorine Binding Sites List in 4zum
Fluorine binding site 6 out
of 6 in the Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of Acetylpolyamine Amidohydrolase From Mycoplana Ramosa in Complex with A Trifluoromethylketone Inhibitor within 5.0Å range:
|
Reference:
C.Decroos,
D.W.Christianson.
Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase. Biochemistry V. 54 4692 2015.
ISSN: ISSN 0006-2960
PubMed: 26200446
DOI: 10.1021/ACS.BIOCHEM.5B00536
Page generated: Sun Dec 13 12:17:26 2020
ISSN: ISSN 0006-2960
PubMed: 26200446
DOI: 10.1021/ACS.BIOCHEM.5B00536
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