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Atomistry » Fluorine » PDB 4zzj-5ah8 » 5aaa | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4zzj-5ah8 » 5aaa » |
Fluorine in PDB 5aaa: Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with CrizotinibEnzymatic activity of Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib
All present enzymatic activity of Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib:
2.7.10.1; Protein crystallography data
The structure of Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib, PDB code: 5aaa
was solved by
M.Mctigue,
Y.Deng,
W.Liu,
A.Brooun,
A.Stewart,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5aaa:
The structure of Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib
(pdb code 5aaa). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib, PDB code: 5aaa: Fluorine binding site 1 out of 1 in 5aaaGo back to Fluorine Binding Sites List in 5aaa
Fluorine binding site 1 out
of 1 in the Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib
Mono view Stereo pair view
Reference:
A.T.Shaw,
L.Friboulet,
I.Leshchiner,
J.F.Gainor,
S.Bergqvist,
A.Brooun,
B.J.Burke,
Y.Deng,
W.Liu,
L.Dardaei,
R.L.Frias,
K.R.Schultz,
J.Logan,
L.P.James,
T.Smeal,
S.Timofeevski,
R.Katayama,
A.J.Iafrate,
L.Le,
M.Mctigue,
G.Getz,
T.W.Johnson,
J.A.Engelman.
Resensitization to Crizotinib By the Lorlatinib Alk Resistance Mutation L1198F. N.Engl.J.Med. V. 374 54 2016.
Page generated: Sun Dec 13 12:18:00 2020
ISSN: ISSN 0028-4793 PubMed: 26698910 DOI: 10.1056/NEJMOA1508887 |
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