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Atomistry » Fluorine » PDB 5aik-5avy » 5ap7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5aik-5avy » 5ap7 » |
Fluorine in PDB 5ap7: Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.Enzymatic activity of Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
All present enzymatic activity of Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.:
2.7.12.1; Protein crystallography data
The structure of Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance., PDB code: 5ap7
was solved by
M.D.Gurden,
I.M.Westwood,
A.Faisal,
S.Naud,
K.M.Cheung,
C.Mcandrew,
A.Wood,
J.Schmitt,
K.Boxall,
G.Mak,
P.Workman,
R.Burke,
S.Hoelder,
J.Blagg,
R.Van Montfort,
S.Linardopoulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
(pdb code 5ap7). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance., PDB code: 5ap7: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 5ap7Go back to Fluorine Binding Sites List in 5ap7
Fluorine binding site 1 out
of 3 in the Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 5ap7Go back to Fluorine Binding Sites List in 5ap7
Fluorine binding site 2 out
of 3 in the Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 5ap7Go back to Fluorine Binding Sites List in 5ap7
Fluorine binding site 3 out
of 3 in the Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
Mono view Stereo pair view
Reference:
M.D.Gurden,
I.M.Westwood,
A.Faisal,
S.Naud,
K.J.Cheung,
C.Mcandrew,
A.Wood,
J.Schmitt,
K.Boxall,
G.Mak,
P.Workman,
R.Burke,
S.Hoelder,
J.Blagg,
R.L.M.Van Montfort,
S.Linardopoulos.
Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res. V. 75 3340 2015.
Page generated: Sun Dec 13 12:18:27 2020
ISSN: ISSN 0008-5472 PubMed: 26202014 DOI: 10.1158/0008-5472.CAN-14-3272 |
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