Fluorine in PDB 5c53: Probing the Structural and Molecular Basis of Nucleotide Selectivity By Human Mitochondrial Dna Polymerase Gamma

Enzymatic activity of Probing the Structural and Molecular Basis of Nucleotide Selectivity By Human Mitochondrial Dna Polymerase Gamma

All present enzymatic activity of Probing the Structural and Molecular Basis of Nucleotide Selectivity By Human Mitochondrial Dna Polymerase Gamma:
2.7.7.7;

Protein crystallography data

The structure of Probing the Structural and Molecular Basis of Nucleotide Selectivity By Human Mitochondrial Dna Polymerase Gamma, PDB code: 5c53 was solved by C.D.Sohl, M.R.Szymanski, A.C.Mislak, C.K.Shumate, S.Amiralaei, R.F.Schinazi, K.S.Anderson, Y.W.Yin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	48.91 / 3.57
*Space group*	P 4₁ 2₁ 2
*Cell size a, b, c (Å), α, β, γ (°)*	217.447, 217.447, 163.593, 90.00, 90.00, 90.00
*R / R_free (%)*	30 / 33.8

Other elements in 5c53:

The structure of Probing the Structural and Molecular Basis of Nucleotide Selectivity By Human Mitochondrial Dna Polymerase Gamma also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Probing the Structural and Molecular Basis of Nucleotide Selectivity By Human Mitochondrial Dna Polymerase Gamma (pdb code 5c53). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Probing the Structural and Molecular Basis of Nucleotide Selectivity By Human Mitochondrial Dna Polymerase Gamma, PDB code: 5c53:

Fluorine binding site 1 out of 1 in 5c53

Go back to

Fluorine Binding Sites List in 5c53

Fluorine binding site 1 out of 1 in the Probing the Structural and Molecular Basis of Nucleotide Selectivity By Human Mitochondrial Dna Polymerase Gamma

Mono view

Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Probing the Structural and Molecular Basis of Nucleotide Selectivity By Human Mitochondrial Dna Polymerase Gamma within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:F4003 b:95.2 occ:1.00	F	A:4Y34003	0.0	95.2	1.0
	C5	A:4Y34003	1.3	0.5	1.0
	C6	A:4Y34003	2.4	0.8	1.0
	C4	A:4Y34003	2.4	0.7	1.0
	N4	A:4Y34003	2.8	0.3	1.0
	N3	A:4Y34003	3.6	0.9	1.0
	N1	A:4Y34003	3.6	0.4	1.0
	C5	P:DOC101	3.7	97.2	1.0
	C4	P:DOC101	3.7	97.9	1.0
	N4	P:DOC101	3.8	99.4	1.0
	C2	A:4Y34003	4.0	0.8	1.0
	C6	P:DOC101	4.3	97.8	1.0
	CD	A:LYS947	4.3	78.9	1.0
	N3	P:DOC101	4.4	94.6	1.0
	O1A	A:4Y34003	4.4	0.3	1.0
	CG1	A:ILE948	4.6	71.5	1.0
	C1'	A:4Y34003	4.8	94.9	1.0
	N1	P:DOC101	4.9	98.9	1.0
	O4'	A:4Y34003	4.9	93.7	1.0
	C2	P:DOC101	4.9	95.0	1.0
	CG	A:LYS947	5.0	79.3	1.0

Reference:

C.D.Sohl, M.R.Szymanski, A.C.Mislak, C.K.Shumate, S.Amiralaei, R.F.Schinazi, K.S.Anderson, Y.W.Yin. Probing the Structural and Molecular Basis of Nucleotide Selectivity By Human Mitochondrial Dna Polymerase Gamma. Proc.Natl.Acad.Sci.Usa V. 112 8596 2015.
ISSN: ESSN 1091-6490
PubMed: 26124101
DOI: 10.1073/PNAS.1421733112

Page generated: Thu Aug 1 08:25:20 2024

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