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Atomistry » Fluorine » PDB 5btf-5cgq » 5c9c | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5btf-5cgq » 5c9c » |
Fluorine in PDB 5c9c: Crystal Structure of Braf(V600E) in Complex with LY3009120 CompndEnzymatic activity of Crystal Structure of Braf(V600E) in Complex with LY3009120 Compnd
All present enzymatic activity of Crystal Structure of Braf(V600E) in Complex with LY3009120 Compnd:
2.7.11.1; Protein crystallography data
The structure of Crystal Structure of Braf(V600E) in Complex with LY3009120 Compnd, PDB code: 5c9c
was solved by
T.Edwards,
J.Abendroth,
L.Chun,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5c9c:
The structure of Crystal Structure of Braf(V600E) in Complex with LY3009120 Compnd also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Braf(V600E) in Complex with LY3009120 Compnd
(pdb code 5c9c). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Braf(V600E) in Complex with LY3009120 Compnd, PDB code: 5c9c: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 5c9cGo back to![]() ![]()
Fluorine binding site 1 out
of 2 in the Crystal Structure of Braf(V600E) in Complex with LY3009120 Compnd
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 2 in 5c9cGo back to![]() ![]()
Fluorine binding site 2 out
of 2 in the Crystal Structure of Braf(V600E) in Complex with LY3009120 Compnd
![]() Mono view ![]() Stereo pair view
Reference:
S.B.Peng,
J.R.Henry,
M.D.Kaufman,
W.P.Lu,
B.D.Smith,
S.Vogeti,
T.J.Rutkoski,
S.Wise,
L.Chun,
Y.Zhang,
R.D.Van Horn,
T.Yin,
X.Zhang,
V.Yadav,
S.H.Chen,
X.Gong,
X.Ma,
Y.Webster,
S.Buchanan,
I.Mochalkin,
L.Huber,
L.Kays,
G.P.Donoho,
J.Walgren,
D.Mccann,
P.Patel,
I.Conti,
G.D.Plowman,
J.J.Starling,
D.L.Flynn.
Inhibition of Raf Isoforms and Active Dimers By LY3009120 Leads to Anti-Tumor Activities in Ras or Braf Mutant Cancers. Cancer Cell V. 28 384 2015.
Page generated: Thu Aug 1 08:26:17 2024
ISSN: ISSN 1535-6108 PubMed: 26343583 DOI: 10.1016/J.CCELL.2015.08.002 |
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