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Atomistry » Fluorine » PDB 5ci0-5dde » 5crz » |
Fluorine in PDB 5crz: Crystal Structure of the First Bromodomain of Human BRD4 in Complex with Benzo[Cd]Indol-2(1H)-One LigandProtein crystallography data
The structure of Crystal Structure of the First Bromodomain of Human BRD4 in Complex with Benzo[Cd]Indol-2(1H)-One Ligand, PDB code: 5crz
was solved by
Y.Zhang,
M.Song,
Z.Liu,
X.Xue,
Y.Xu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5crz:
The structure of Crystal Structure of the First Bromodomain of Human BRD4 in Complex with Benzo[Cd]Indol-2(1H)-One Ligand also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with Benzo[Cd]Indol-2(1H)-One Ligand
(pdb code 5crz). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with Benzo[Cd]Indol-2(1H)-One Ligand, PDB code: 5crz: Fluorine binding site 1 out of 1 in 5crzGo back to Fluorine Binding Sites List in 5crz
Fluorine binding site 1 out
of 1 in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with Benzo[Cd]Indol-2(1H)-One Ligand
Mono view Stereo pair view
Reference:
X.Xue,
Y.Zhang,
Z.Liu,
M.Song,
Y.Xing,
Q.Xiang,
Z.Wang,
Z.Tu,
Y.Zhou,
K.Ding,
Y.Xu.
Discovery of Benzo[Cd]Indol-2(1H)-Ones As Potent and Specific Bet Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem. V. 59 1565 2016.
Page generated: Sun Dec 13 12:20:24 2020
ISSN: ISSN 0022-2623 PubMed: 26731490 DOI: 10.1021/ACS.JMEDCHEM.5B01511 |
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