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Atomistry » Fluorine » PDB 5ddf-5dy7 » 5de1 » |
Fluorine in PDB 5de1: Crystal Structure of Human IDH1 in Complex with GSK321AEnzymatic activity of Crystal Structure of Human IDH1 in Complex with GSK321A
All present enzymatic activity of Crystal Structure of Human IDH1 in Complex with GSK321A:
1.1.1.42; Protein crystallography data
The structure of Crystal Structure of Human IDH1 in Complex with GSK321A, PDB code: 5de1
was solved by
N.O.Concha,
A.Smallwood,
H.Qi,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human IDH1 in Complex with GSK321A
(pdb code 5de1). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human IDH1 in Complex with GSK321A, PDB code: 5de1: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 5de1Go back to Fluorine Binding Sites List in 5de1
Fluorine binding site 1 out
of 2 in the Crystal Structure of Human IDH1 in Complex with GSK321A
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 5de1Go back to Fluorine Binding Sites List in 5de1
Fluorine binding site 2 out
of 2 in the Crystal Structure of Human IDH1 in Complex with GSK321A
Mono view Stereo pair view
Reference:
U.C.Okoye-Okafor,
B.Bartholdy,
J.Cartier,
E.N.Gao,
B.Pietrak,
A.R.Rendina,
C.Rominger,
C.Quinn,
A.Smallwood,
K.J.Wiggall,
A.J.Reif,
S.J.Schmidt,
H.Qi,
H.Zhao,
G.Joberty,
M.Faelth-Savitski,
M.Bantscheff,
G.Drewes,
C.Duraiswami,
P.Brady,
A.Groy,
S.R.Narayanagari,
I.Antony-Debre,
K.Mitchell,
H.R.Wang,
Y.R.Kao,
M.Christopeit,
L.Carvajal,
L.Barreyro,
E.Paietta,
H.Makishima,
B.Will,
N.Concha,
N.D.Adams,
B.Schwartz,
M.T.Mccabe,
J.Maciejewski,
A.Verma,
U.Steidl.
New IDH1 Mutant Inhibitors For Treatment of Acute Myeloid Leukemia. Nat.Chem.Biol. V. 11 878 2015.
Page generated: Sun Dec 13 12:20:49 2020
ISSN: ESSN 1552-4469 PubMed: 26436839 DOI: 10.1038/NCHEMBIO.1930 |
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