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Atomistry » Fluorine » PDB 5dz3-5ese » 5ehe | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5dz3-5ese » 5ehe » |
Fluorine in PDB 5ehe: Crystal Structure of Human Carbonic Anhydrase Isozyme II with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]BenzenesulfonamideEnzymatic activity of Crystal Structure of Human Carbonic Anhydrase Isozyme II with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide
All present enzymatic activity of Crystal Structure of Human Carbonic Anhydrase Isozyme II with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide:
4.2.1.1; Protein crystallography data
The structure of Crystal Structure of Human Carbonic Anhydrase Isozyme II with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide, PDB code: 5ehe
was solved by
A.Smirnov,
E.Manakova,
S.Grazulis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5ehe:
The structure of Crystal Structure of Human Carbonic Anhydrase Isozyme II with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Carbonic Anhydrase Isozyme II with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide
(pdb code 5ehe). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Human Carbonic Anhydrase Isozyme II with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide, PDB code: 5ehe: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 5eheGo back to Fluorine Binding Sites List in 5ehe
Fluorine binding site 1 out
of 3 in the Crystal Structure of Human Carbonic Anhydrase Isozyme II with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 5eheGo back to Fluorine Binding Sites List in 5ehe
Fluorine binding site 2 out
of 3 in the Crystal Structure of Human Carbonic Anhydrase Isozyme II with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 5eheGo back to Fluorine Binding Sites List in 5ehe
Fluorine binding site 3 out
of 3 in the Crystal Structure of Human Carbonic Anhydrase Isozyme II with 3- (Benzylamino)-2,5,6-Trifluoro-4-[(2-Hydroxyethyl) Sulfonyl]Benzenesulfonamide
Mono view Stereo pair view
Reference:
A.Zubriene,
A.Smirnov,
V.Dudutiene,
D.D.Timm,
J.Matuliene,
V.Michailoviene,
A.Zaksauskas,
E.Manakova,
S.Grazulis,
D.Matulis.
Intrinsic Thermodynamics and Structures of 2,4- and 3,4-Substituted Fluorinated Benzenesulfonamides Binding to Carbonic Anhydrases. Chemmedchem V. 12 161 2017.
Page generated: Thu Aug 1 09:02:42 2024
ISSN: ESSN 1860-7187 PubMed: 28001003 DOI: 10.1002/CMDC.201600509 |
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