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Fluorine in PDB 5eoz: Mutagenicity of 7-Benzyl Guanine Lesion and Replication By Human Dna Polymerase Beta

Enzymatic activity of Mutagenicity of 7-Benzyl Guanine Lesion and Replication By Human Dna Polymerase Beta

All present enzymatic activity of Mutagenicity of 7-Benzyl Guanine Lesion and Replication By Human Dna Polymerase Beta:
2.7.7.7;

Protein crystallography data

The structure of Mutagenicity of 7-Benzyl Guanine Lesion and Replication By Human Dna Polymerase Beta, PDB code: 5eoz was solved by M.C.Koag, S.Lee, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.82 / 2.09
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 50.754, 80.015, 55.589, 90.00, 107.76, 90.00
R / Rfree (%) 18.4 / 23.8

Other elements in 5eoz:

The structure of Mutagenicity of 7-Benzyl Guanine Lesion and Replication By Human Dna Polymerase Beta also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Sodium (Na) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Mutagenicity of 7-Benzyl Guanine Lesion and Replication By Human Dna Polymerase Beta (pdb code 5eoz). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Mutagenicity of 7-Benzyl Guanine Lesion and Replication By Human Dna Polymerase Beta, PDB code: 5eoz:

Fluorine binding site 1 out of 1 in 5eoz

Go back to Fluorine Binding Sites List in 5eoz
Fluorine binding site 1 out of 1 in the Mutagenicity of 7-Benzyl Guanine Lesion and Replication By Human Dna Polymerase Beta


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Mutagenicity of 7-Benzyl Guanine Lesion and Replication By Human Dna Polymerase Beta within 5.0Å range:
probe atom residue distance (Å) B Occ
T:F6

b:24.3
occ:1.00
 F T:GFL6 0.0 24.3 1.0
C2' T:GFL6 1.4 24.1 1.0
C3' T:GFL6 2.3 23.4 1.0
C1' T:GFL6 2.4 22.9 1.0
N9 T:GFL6 2.8 23.1 1.0
C8 T:GFL6 2.8 25.4 1.0
O5' T:GFL6 3.1 36.9 1.0
O4' T:GFL6 3.1 24.8 1.0
C4' T:GFL6 3.1 25.1 1.0
O3' T:GFL6 3.5 24.1 1.0
C7 T:DT7 3.6 17.1 1.0
C5' T:GFL6 3.6 27.2 1.0
C6 T:DT7 3.6 18.6 1.0
C5 T:DT7 3.8 17.7 1.0
C4 T:GFL6 4.0 18.5 1.0
OP2 T:DT7 4.0 25.8 1.0
N7 T:GFL6 4.1 22.7 1.0
P T:DT7 4.2 26.2 1.0
O5' T:DT7 4.2 24.1 1.0
P T:GFL6 4.4 42.1 1.0
O4' T:DT7 4.5 19.6 1.0
O2P T:GFL6 4.5 43.5 1.0
N1 T:DT7 4.6 20.1 1.0
C5 T:GFL6 4.6 18.5 1.0
N3 T:GFL6 4.9 18.4 1.0
C4 T:DT7 5.0 21.3 1.0

Reference:

Y.Kou, M.C.Koag, S.Lee. Structural and Kinetic Studies of the Effect of Guanine-N7 Alkylation and Metal Cofactors on Dna Replication. Biochemistry 2018.
ISSN: ISSN 1520-4995
PubMed: 29957995
DOI: 10.1021/ACS.BIOCHEM.8B00331
Page generated: Thu Aug 1 09:09:49 2024

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