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Atomistry » Fluorine » PDB 5esf-5fct » 5eyd | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5esf-5fct » 5eyd » |
Fluorine in PDB 5eyd: Crystal Structure of C-Met in Complex with Amg 337Enzymatic activity of Crystal Structure of C-Met in Complex with Amg 337
All present enzymatic activity of Crystal Structure of C-Met in Complex with Amg 337:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of C-Met in Complex with Amg 337, PDB code: 5eyd
was solved by
D.A.Whittington,
A.M.Long,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of C-Met in Complex with Amg 337
(pdb code 5eyd). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of C-Met in Complex with Amg 337, PDB code: 5eyd: Fluorine binding site 1 out of 1 in 5eydGo back to Fluorine Binding Sites List in 5eyd
Fluorine binding site 1 out
of 1 in the Crystal Structure of C-Met in Complex with Amg 337
Mono view Stereo pair view
Reference:
A.A.Boezio,
K.W.Copeland,
K.Rex,
B.K Albrecht,
D.Bauer,
S.F.Bellon,
C.Boezio,
M.A.Broome,
D.Choquette,
A.Coxon,
I.Dussault,
S.Hirai,
R.Lewis,
M.H.Lin,
J.Lohman,
J.Liu,
E.A.Peterson,
M.Potashman,
R.Shimanovich,
Y.Teffera,
D.A.Whittington,
K.R.Vaida,
J.C.Harmange.
Discovery of (R)-6-(1-(8-Fluoro-6-(1-Methyl-1H-Pyrazol-4-Yl)-[1,2, 4]Triazolo[4,3-A]Pyridin-3-Yl)Ethyl)-3-(2-Methoxyethoxy)-1, 6-Naphthyridin-5(6H)-One (Amg 337), A Potent and Selective Inhibitor of Met with High Unbound Target Coverage and Robust in Vivo Antitumor Activity. J.Med.Chem. V. 59 2328 2016.
Page generated: Sun Dec 13 12:22:01 2020
ISSN: ISSN 0022-2623 PubMed: 26812066 DOI: 10.1021/ACS.JMEDCHEM.5B01716 |
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