Fluorine »
PDB 5esf-5fct »
5fbn »
Fluorine in PDB 5fbn: Btk Kinase Domain with Inhibitor 1
Enzymatic activity of Btk Kinase Domain with Inhibitor 1
All present enzymatic activity of Btk Kinase Domain with Inhibitor 1:
2.7.10.2;
2.7.10.2;
Protein crystallography data
The structure of Btk Kinase Domain with Inhibitor 1, PDB code: 5fbn
was solved by
H.C.A.Raaijmakers,
D.Vu-Pham,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 103.05 / 1.80 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 38.262, 71.475, 103.056, 90.00, 90.68, 90.00 |
| R / Rfree (%) | 17.9 / 22.6 |
Other elements in 5fbn:
The structure of Btk Kinase Domain with Inhibitor 1 also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Btk Kinase Domain with Inhibitor 1
(pdb code 5fbn). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Btk Kinase Domain with Inhibitor 1, PDB code: 5fbn:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Btk Kinase Domain with Inhibitor 1, PDB code: 5fbn:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 5fbn
Go back to
Fluorine Binding Sites List in 5fbn
Fluorine binding site 1 out
of 6 in the Btk Kinase Domain with Inhibitor 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Btk Kinase Domain with Inhibitor 1 within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 5fbn
Go back to
Fluorine Binding Sites List in 5fbn
Fluorine binding site 2 out
of 6 in the Btk Kinase Domain with Inhibitor 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Btk Kinase Domain with Inhibitor 1 within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 5fbn
Go back to
Fluorine Binding Sites List in 5fbn
Fluorine binding site 3 out
of 6 in the Btk Kinase Domain with Inhibitor 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Btk Kinase Domain with Inhibitor 1 within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 5fbn
Go back to
Fluorine Binding Sites List in 5fbn
Fluorine binding site 4 out
of 6 in the Btk Kinase Domain with Inhibitor 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Btk Kinase Domain with Inhibitor 1 within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 5fbn
Go back to
Fluorine Binding Sites List in 5fbn
Fluorine binding site 5 out
of 6 in the Btk Kinase Domain with Inhibitor 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Btk Kinase Domain with Inhibitor 1 within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 5fbn
Go back to
Fluorine Binding Sites List in 5fbn
Fluorine binding site 6 out
of 6 in the Btk Kinase Domain with Inhibitor 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Btk Kinase Domain with Inhibitor 1 within 5.0Å range:
|
Reference:
J.Liu,
D.Guiadeen,
A.Krikorian,
X.Gao,
J.Wang,
S.B.Boga,
A.B.Alhassan,
Y.Yu,
H.Vaccaro,
S.Liu,
C.Yang,
H.Wu,
A.Cooper,
J.De Man,
A.Kaptein,
K.Maloney,
V.Hornak,
Y.D.Gao,
T.O.Fischmann,
H.Raaijmakers,
D.Vu-Pham,
J.Presland,
M.Mansueto,
Z.Xu,
E.Leccese,
J.Zhang-Hoover,
I.Knemeyer,
C.G.Garlisi,
N.Bays,
P.Stivers,
P.E.Brandish,
A.Hicks,
R.Kim,
J.A.Kozlowski.
Discovery of 8-Amino-Imidazo[1,5-A]Pyrazines As Reversible Btk Inhibitors For the Treatment of Rheumatoid Arthritis. Acs Med.Chem.Lett. V. 7 198 2016.
ISSN: ISSN 1948-5875
PubMed: 26985298
DOI: 10.1021/ACSMEDCHEMLETT.5B00463
Page generated: Thu Aug 1 09:19:54 2024
ISSN: ISSN 1948-5875
PubMed: 26985298
DOI: 10.1021/ACSMEDCHEMLETT.5B00463
Last articles
Zn in 9J0NZn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
