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Atomistry » Fluorine » PDB 5fd2-5g3j » 5fee | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5fd2-5g3j » 5fee » |
Fluorine in PDB 5fee: Egfr Kinase Domain T790M Mutant in Complex with A Covalent Aminobenzimidazole Inhibitor.Enzymatic activity of Egfr Kinase Domain T790M Mutant in Complex with A Covalent Aminobenzimidazole Inhibitor.
All present enzymatic activity of Egfr Kinase Domain T790M Mutant in Complex with A Covalent Aminobenzimidazole Inhibitor.:
2.7.10.1; Protein crystallography data
The structure of Egfr Kinase Domain T790M Mutant in Complex with A Covalent Aminobenzimidazole Inhibitor., PDB code: 5fee
was solved by
M.Didonato,
G.Spraggon,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Egfr Kinase Domain T790M Mutant in Complex with A Covalent Aminobenzimidazole Inhibitor.
(pdb code 5fee). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Egfr Kinase Domain T790M Mutant in Complex with A Covalent Aminobenzimidazole Inhibitor., PDB code: 5fee: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 5feeGo back to Fluorine Binding Sites List in 5fee
Fluorine binding site 1 out
of 3 in the Egfr Kinase Domain T790M Mutant in Complex with A Covalent Aminobenzimidazole Inhibitor.
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 5feeGo back to Fluorine Binding Sites List in 5fee
Fluorine binding site 2 out
of 3 in the Egfr Kinase Domain T790M Mutant in Complex with A Covalent Aminobenzimidazole Inhibitor.
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 5feeGo back to Fluorine Binding Sites List in 5fee
Fluorine binding site 3 out
of 3 in the Egfr Kinase Domain T790M Mutant in Complex with A Covalent Aminobenzimidazole Inhibitor.
Mono view Stereo pair view
Reference:
G.Lelais,
R.Epple,
T.H.Marsilje,
Y.O.Long,
M.Mcneill,
B.Chen,
W.Lu,
J.Anumolu,
S.Badiger,
B.Bursulaya,
M.Didonato,
R.Fong,
J.Juarez,
J.Li,
M.Manuia,
D.E.Mason,
P.Gordon,
T.Groessl,
K.Johnson,
Y.Jia,
S.Kasibhatla,
C.Li,
J.Isbell,
G.Spraggon,
S.Bender,
P.Y.Michellys.
Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(Dimethylamino) But-2-Enoyl]Azepan-3-Yl)-1H-Benzo[D]Imidazol-2-Yl) -2-Methylisonicotinamide (EGF816), A Novel, Potent, and Wt Sparing Covalent Inhibitor of Oncogenic (L858R, EX19DEL) and Resistant (T790M) Egfr Mutants For the Treatment of Egfr Mutant Non-Small-Cell Lung Cancers. J.Med.Chem. V. 59 6671 2016.
Page generated: Thu Aug 1 09:23:11 2024
ISSN: ISSN 0022-2623 PubMed: 27433829 DOI: 10.1021/ACS.JMEDCHEM.5B01985 |
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