Atomistry » Fluorine » PDB 5he2-5hti » 5he2
Atomistry »
  Fluorine »
    PDB 5he2-5hti »
      5he2 »

Fluorine in PDB 5he2: Bovine GRK2 in Complex with Gbetagamma Subunits and CCG224406

Enzymatic activity of Bovine GRK2 in Complex with Gbetagamma Subunits and CCG224406

All present enzymatic activity of Bovine GRK2 in Complex with Gbetagamma Subunits and CCG224406:
2.7.11.15;

Protein crystallography data

The structure of Bovine GRK2 in Complex with Gbetagamma Subunits and CCG224406, PDB code: 5he2 was solved by M.C.Cato, J.Waninger-Saroni, J.J.G.Tesmer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.79
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 60.729, 241.950, 213.668, 90.00, 90.00, 90.00
R / Rfree (%) 19.8 / 27.7

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Bovine GRK2 in Complex with Gbetagamma Subunits and CCG224406 (pdb code 5he2). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Bovine GRK2 in Complex with Gbetagamma Subunits and CCG224406, PDB code: 5he2:

Fluorine binding site 1 out of 1 in 5he2

Go back to Fluorine Binding Sites List in 5he2
Fluorine binding site 1 out of 1 in the Bovine GRK2 in Complex with Gbetagamma Subunits and CCG224406


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Bovine GRK2 in Complex with Gbetagamma Subunits and CCG224406 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F701

b:72.7
occ:1.00
F A:F0S701 0.0 72.7 1.0
C15 A:F0S701 1.4 67.1 1.0
C10 A:F0S701 2.4 63.7 1.0
C14 A:F0S701 2.4 66.5 1.0
O2 A:F0S701 2.7 64.0 1.0
C9 A:F0S701 2.8 62.8 1.0
O A:GLY203 3.3 66.4 1.0
CD1 A:LEU222 3.4 59.6 1.0
N A:GLY203 3.4 67.8 1.0
C A:GLY203 3.5 66.7 1.0
C11 A:F0S701 3.6 64.6 1.0
C13 A:F0S701 3.7 63.5 1.0
CA A:GLY203 3.8 67.3 1.0
N A:F0S701 3.9 61.8 1.0
CE A:LYS220 4.0 63.6 1.0
C A:PHE202 4.1 65.2 1.0
N A:GLY200 4.1 68.2 1.0
C12 A:F0S701 4.1 63.6 1.0
N A:GLU204 4.2 66.6 1.0
CG A:LEU222 4.3 59.3 1.0
N A:PHE202 4.3 67.8 1.0
CA A:GLY200 4.5 69.7 1.0
CB A:PHE202 4.5 65.7 1.0
CA A:PHE202 4.5 65.5 1.0
CG A:LYS220 4.5 58.0 1.0
C A:F0S701 4.6 59.6 1.0
NZ A:LYS220 4.6 64.7 1.0
C A:GLY200 4.7 70.8 1.0
CD A:LYS220 4.7 60.5 1.0
O A:GLY200 4.8 69.8 1.0
C8 A:F0S701 4.8 62.4 1.0
O A:PHE202 4.9 63.2 1.0
CA A:GLU204 4.9 69.1 1.0

Reference:

H.V.Waldschmidt, K.T.Homan, O.Cruz-Rodriguez, M.C.Cato, J.Waninger-Saroni, K.M.Larimore, A.Cannavo, J.Song, J.Y.Cheung, P.D.Kirchhoff, W.J.Koch, J.J.Tesmer, S.D.Larsen. Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J.Med.Chem. V. 59 3793 2016.
ISSN: ISSN 0022-2623
PubMed: 27050625
DOI: 10.1021/ACS.JMEDCHEM.5B02000
Page generated: Sun Dec 13 12:23:30 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy