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Fluorine in PDB 5hpb: Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine
Enzymatic activity of Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine
All present enzymatic activity of Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine:
1.5.1.3;
1.5.1.3;
Protein crystallography data
The structure of Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine, PDB code: 5hpb
was solved by
V.Cody,
A.Ganjee,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 34.09 / 1.65 |
| Space group | H 3 |
| Cell size a, b, c (Å), α, β, γ (°) | 85.845, 85.845, 76.725, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 23.6 / 29.3 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine
(pdb code 5hpb). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine, PDB code: 5hpb:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine, PDB code: 5hpb:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 5hpb
Go back to
Fluorine Binding Sites List in 5hpb
Fluorine binding site 1 out
of 3 in the Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 5hpb
Go back to
Fluorine Binding Sites List in 5hpb
Fluorine binding site 2 out
of 3 in the Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 5hpb
Go back to
Fluorine Binding Sites List in 5hpb
Fluorine binding site 3 out
of 3 in the Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine within 5.0Å range:
|
Reference:
V.Cody,
A.Gangjee.
Human Dihydrofolate Reductase Ternary Complex with A Series Offluorine Substituted 5-Methyl-6-Phenythio)Thieno[2,3-D]Pyrimidine-2,4-Diamines To Be Published.
Page generated: Sun Dec 13 12:23:50 2020
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