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Fluorine in PDB 5i8p: Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor
Enzymatic activity of Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor
All present enzymatic activity of Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor:
3.1.1.47;
3.1.1.47;
Protein crystallography data
The structure of Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor, PDB code: 5i8p
was solved by
Q.F.Liu,
Y.C.Xu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 44.02 / 2.37 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 115.820, 82.750, 96.390, 90.00, 115.44, 90.00 |
| R / Rfree (%) | 20.6 / 27.5 |
Other elements in 5i8p:
The structure of Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor
(pdb code 5i8p). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 10 binding sites of Fluorine where determined in the Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor, PDB code: 5i8p:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;
In total 10 binding sites of Fluorine where determined in the Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor, PDB code: 5i8p:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;
Fluorine binding site 1 out of 10 in 5i8p
Go back to
Fluorine Binding Sites List in 5i8p
Fluorine binding site 1 out
of 10 in the Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 10 in 5i8p
Go back to
Fluorine Binding Sites List in 5i8p
Fluorine binding site 2 out
of 10 in the Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 10 in 5i8p
Go back to
Fluorine Binding Sites List in 5i8p
Fluorine binding site 3 out
of 10 in the Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 10 in 5i8p
Go back to
Fluorine Binding Sites List in 5i8p
Fluorine binding site 4 out
of 10 in the Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor within 5.0Å range:
|
Fluorine binding site 5 out of 10 in 5i8p
Go back to
Fluorine Binding Sites List in 5i8p
Fluorine binding site 5 out
of 10 in the Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor within 5.0Å range:
|
Fluorine binding site 6 out of 10 in 5i8p
Go back to
Fluorine Binding Sites List in 5i8p
Fluorine binding site 6 out
of 10 in the Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor within 5.0Å range:
|
Fluorine binding site 7 out of 10 in 5i8p
Go back to
Fluorine Binding Sites List in 5i8p
Fluorine binding site 7 out
of 10 in the Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor within 5.0Å range:
|
Fluorine binding site 8 out of 10 in 5i8p
Go back to
Fluorine Binding Sites List in 5i8p
Fluorine binding site 8 out
of 10 in the Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor within 5.0Å range:
|
Fluorine binding site 9 out of 10 in 5i8p
Go back to
Fluorine Binding Sites List in 5i8p
Fluorine binding site 9 out
of 10 in the Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 9 of Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor within 5.0Å range:
|
Fluorine binding site 10 out of 10 in 5i8p
Go back to
Fluorine Binding Sites List in 5i8p
Fluorine binding site 10 out
of 10 in the Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 10 of Crystal Structure of LP_PLA2 in Complex with Novel Inhibitor within 5.0Å range:
|
Reference:
Q.F.Liu,
X.D.Chen,
W.Y.Chen,
X.J.Yuan,
H.X.Su,
J.H.Shen,
Y.C.Xu.
Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed Between Lipoprotein-Associated Phospholipase A2 and Inhibitors J.Med.Chem. V. 59 5115 2016.
ISSN: ISSN 0022-2623
PubMed: 27078579
DOI: 10.1021/ACS.JMEDCHEM.6B00282
Page generated: Thu Aug 1 10:07:59 2024
ISSN: ISSN 0022-2623
PubMed: 27078579
DOI: 10.1021/ACS.JMEDCHEM.6B00282
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