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Atomistry » Fluorine » PDB 5ifd-5j82 » 5ix0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5ifd-5j82 » 5ix0 » |
Fluorine in PDB 5ix0: HDAC2 with Ligand BRD7232Enzymatic activity of HDAC2 with Ligand BRD7232
All present enzymatic activity of HDAC2 with Ligand BRD7232:
3.5.1.98; Protein crystallography data
The structure of HDAC2 with Ligand BRD7232, PDB code: 5ix0
was solved by
S.Steinbacher,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5ix0:
The structure of HDAC2 with Ligand BRD7232 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the HDAC2 with Ligand BRD7232
(pdb code 5ix0). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the HDAC2 with Ligand BRD7232, PDB code: 5ix0: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 5ix0Go back to Fluorine Binding Sites List in 5ix0
Fluorine binding site 1 out
of 3 in the HDAC2 with Ligand BRD7232
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 5ix0Go back to Fluorine Binding Sites List in 5ix0
Fluorine binding site 2 out
of 3 in the HDAC2 with Ligand BRD7232
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 5ix0Go back to Fluorine Binding Sites List in 5ix0
Fluorine binding site 3 out
of 3 in the HDAC2 with Ligand BRD7232
Mono view Stereo pair view
Reference:
F.F.Wagner,
M.Weiwer,
S.Steinbacher,
A.Schomburg,
P.Reinemer,
J.P.Gale,
A.J.Campbell,
S.L.Fisher,
W.N.Zhao,
S.A.Reis,
K.M.Hennig,
M.Thomas,
P.Muller,
M.R.Jefson,
D.M.Fass,
S.J.Haggarty,
Y.L.Zhang,
E.B.Holson.
Kinetic and Structural Insights Into the Binding of Histone Deacetylase 1 and 2 (HDAC1, 2) Inhibitors. Bioorg.Med.Chem. V. 24 4008 2016.
Page generated: Thu Aug 1 10:20:50 2024
ISSN: ESSN 1464-3391 PubMed: 27377864 DOI: 10.1016/J.BMC.2016.06.040 |
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