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Fluorine in PDB 5jha: Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN2
Enzymatic activity of Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN2
All present enzymatic activity of Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN2:
2.7.1.153; 2.7.11.1;
2.7.1.153; 2.7.11.1;
Protein crystallography data
The structure of Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN2, PDB code: 5jha
was solved by
J.E.Burke,
A.J.Inglis,
R.L.Williams,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 61.51 / 2.51 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 144.560, 68.040, 106.730, 90.00, 95.36, 90.00 |
| R / Rfree (%) | 20.2 / 24.6 |
Other elements in 5jha:
The structure of Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN2 also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN2
(pdb code 5jha). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN2, PDB code: 5jha:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN2, PDB code: 5jha:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 5jha
Go back to
Fluorine Binding Sites List in 5jha
Fluorine binding site 1 out
of 3 in the Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN2 within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 5jha
Go back to
Fluorine Binding Sites List in 5jha
Fluorine binding site 2 out
of 3 in the Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN2 within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 5jha
Go back to
Fluorine Binding Sites List in 5jha
Fluorine binding site 3 out
of 3 in the Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN2 within 5.0Å range:
|
Reference:
T.Bohnacker,
A.E.Prota,
F.Beaufils,
J.E.Burke,
A.Melone,
A.J.Inglis,
D.Rageot,
A.M.Sele,
V.Cmiljanovic,
N.Cmiljanovic,
K.Bargsten,
A.Aher,
A.Akhmanova,
J.F.Diaz,
D.Fabbro,
M.Zvelebil,
R.L.Williams,
M.O.Steinmetz,
M.P.Wymann.
Deconvolution of Buparlisib'S Mechanism of Action Defines Specific PI3K and Tubulin Inhibitors For Therapeutic Intervention. Nat Commun V. 8 14683 2017.
ISSN: ESSN 2041-1723
PubMed: 28276440
DOI: 10.1038/NCOMMS14683
Page generated: Thu Aug 1 10:31:50 2024
ISSN: ESSN 2041-1723
PubMed: 28276440
DOI: 10.1038/NCOMMS14683
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