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Atomistry » Fluorine » PDB 5j8m-5jw1 » 5jhb | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5j8m-5jw1 » 5jhb » |
Fluorine in PDB 5jhb: Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN3Enzymatic activity of Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN3
All present enzymatic activity of Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN3:
2.7.1.153; 2.7.11.1; Protein crystallography data
The structure of Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN3, PDB code: 5jhb
was solved by
J.E.Burke,
A.J.Inglis,
R.L.Williams,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5jhb:
The structure of Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN3 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN3
(pdb code 5jhb). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN3, PDB code: 5jhb: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 5jhbGo back to Fluorine Binding Sites List in 5jhb
Fluorine binding site 1 out
of 3 in the Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN3
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 5jhbGo back to Fluorine Binding Sites List in 5jhb
Fluorine binding site 2 out
of 3 in the Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN3
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 5jhbGo back to Fluorine Binding Sites List in 5jhb
Fluorine binding site 3 out
of 3 in the Structure of Phosphoinositide 3-Kinase Gamma (PI3K) Bound to the Potent Inhibitor PIKIN3
Mono view Stereo pair view
Reference:
T.Bohnacker,
A.E.Prota,
F.Beaufils,
J.E.Burke,
A.Melone,
A.J.Inglis,
D.Rageot,
A.M.Sele,
V.Cmiljanovic,
N.Cmiljanovic,
K.Bargsten,
A.Aher,
A.Akhmanova,
J.F.Diaz,
D.Fabbro,
M.Zvelebil,
R.L.Williams,
M.O.Steinmetz,
M.P.Wymann.
Deconvolution of Buparlisib'S Mechanism of Action Defines Specific PI3K and Tubulin Inhibitors For Therapeutic Intervention. Nat Commun V. 8 14683 2017.
Page generated: Thu Aug 1 10:31:53 2024
ISSN: ESSN 2041-1723 PubMed: 28276440 DOI: 10.1038/NCOMMS14683 |
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