|
Atomistry » Fluorine » PDB 5ko1-5lca » 5kyj | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5ko1-5lca » 5kyj » |
Fluorine in PDB 5kyj: Brain Penetrant Liver X Receptor (Lxr) Modulators Based on A 2,4,5,6- Tetrahydropyrrolo[3,4-C]Pyrazole CoreProtein crystallography data
The structure of Brain Penetrant Liver X Receptor (Lxr) Modulators Based on A 2,4,5,6- Tetrahydropyrrolo[3,4-C]Pyrazole Core, PDB code: 5kyj
was solved by
G.Chen,
B.M.Mckeever,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Brain Penetrant Liver X Receptor (Lxr) Modulators Based on A 2,4,5,6- Tetrahydropyrrolo[3,4-C]Pyrazole Core
(pdb code 5kyj). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Brain Penetrant Liver X Receptor (Lxr) Modulators Based on A 2,4,5,6- Tetrahydropyrrolo[3,4-C]Pyrazole Core, PDB code: 5kyj: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 5kyjGo back to Fluorine Binding Sites List in 5kyj
Fluorine binding site 1 out
of 2 in the Brain Penetrant Liver X Receptor (Lxr) Modulators Based on A 2,4,5,6- Tetrahydropyrrolo[3,4-C]Pyrazole Core
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 5kyjGo back to Fluorine Binding Sites List in 5kyj
Fluorine binding site 2 out
of 2 in the Brain Penetrant Liver X Receptor (Lxr) Modulators Based on A 2,4,5,6- Tetrahydropyrrolo[3,4-C]Pyrazole Core
Mono view Stereo pair view
Reference:
C.M.Tice,
P.B.Noto,
K.Y.Fan,
W.Zhao,
S.D.Lotesta,
C.Dong,
A.P.Marcus,
Y.J.Zheng,
G.Chen,
Z.Wu,
R.Van Orden,
J.Zhou,
Y.Bukhtiyarov,
Y.Zhao,
K.Lipinski,
L.Howard,
J.Guo,
G.Kandpal,
S.Meng,
A.Hardy,
P.Krosky,
R.E.Gregg,
K.Leftheris,
B.M.Mckeever,
S.B.Singh,
D.Lala,
G.M.Mcgeehan,
L.Zhuang,
D.A.Claremon.
Brain Penetrant Liver X Receptor (Lxr) Modulators Based on A 2,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazole Core. Bioorg.Med.Chem.Lett. V. 26 5044 2016.
Page generated: Thu Aug 1 11:15:42 2024
ISSN: ESSN 1464-3405 PubMed: 27599745 DOI: 10.1016/J.BMCL.2016.08.089 |
Last articlesZn in 9JYWZn in 9IR4 Zn in 9IR3 Zn in 9GMX Zn in 9GMW Zn in 9JEJ Zn in 9ERF Zn in 9ERE Zn in 9EGV Zn in 9EGW |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |