Fluorine »
PDB 5lck-5lz4 »
5lp1 »
Fluorine in PDB 5lp1: Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
Enzymatic activity of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
All present enzymatic activity of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.:
3.1.1.47;
3.1.1.47;
Protein crystallography data
The structure of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution., PDB code: 5lp1
was solved by
D.Somers,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 1.91 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 100.280, 91.560, 51.650, 90.00, 111.88, 90.00 |
| R / Rfree (%) | 16.2 / 19.2 |
Other elements in 5lp1:
The structure of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution. also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
(pdb code 5lp1). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution., PDB code: 5lp1:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution., PDB code: 5lp1:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 5lp1
Go back to
Fluorine Binding Sites List in 5lp1
Fluorine binding site 1 out
of 4 in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution. within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 5lp1
Go back to
Fluorine Binding Sites List in 5lp1
Fluorine binding site 2 out
of 4 in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution. within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 5lp1
Go back to
Fluorine Binding Sites List in 5lp1
Fluorine binding site 3 out
of 4 in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution. within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 5lp1
Go back to
Fluorine Binding Sites List in 5lp1
Fluorine binding site 4 out
of 4 in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution. within 5.0Å range:
|
Reference:
N.D.Measom,
K.D.Down,
D.J.Hirst,
C.Jamieson,
E.S.Manas,
V.K.Patel,
D.O.Somers.
Investigation of A Bicyclo[1.1.1]Pentane As A Phenyl Replacement Within An LPPLA2 Inhibitor. Acs Med Chem Lett V. 8 43 2017.
ISSN: ISSN 1948-5875
PubMed: 28105273
DOI: 10.1021/ACSMEDCHEMLETT.6B00281
Page generated: Sun Dec 13 12:27:17 2020
ISSN: ISSN 1948-5875
PubMed: 28105273
DOI: 10.1021/ACSMEDCHEMLETT.6B00281
Last articles
Zn in 8WB0Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
