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Fluorine in PDB 5lp1: Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
Enzymatic activity of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
All present enzymatic activity of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.:
3.1.1.47;
3.1.1.47;
Protein crystallography data
The structure of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution., PDB code: 5lp1
was solved by
D.Somers,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 1.91 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 100.280, 91.560, 51.650, 90.00, 111.88, 90.00 |
| R / Rfree (%) | 16.2 / 19.2 |
Other elements in 5lp1:
The structure of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution. also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
(pdb code 5lp1). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution., PDB code: 5lp1:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution., PDB code: 5lp1:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 5lp1
Go back to
Fluorine Binding Sites List in 5lp1
Fluorine binding site 1 out
of 4 in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution. within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 5lp1
Go back to
Fluorine Binding Sites List in 5lp1
Fluorine binding site 2 out
of 4 in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution. within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 5lp1
Go back to
Fluorine Binding Sites List in 5lp1
Fluorine binding site 3 out
of 4 in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution. within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 5lp1
Go back to
Fluorine Binding Sites List in 5lp1
Fluorine binding site 4 out
of 4 in the Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Human Lipoprotein-Associated Phospholipase A2 in Complex with A [1.1.1]Bicyclopentane-Containing Inhibitor at 1.91A Resolution. within 5.0Å range:
|
Reference:
N.D.Measom,
K.D.Down,
D.J.Hirst,
C.Jamieson,
E.S.Manas,
V.K.Patel,
D.O.Somers.
Investigation of A Bicyclo[1.1.1]Pentane As A Phenyl Replacement Within An LPPLA2 Inhibitor. Acs Med Chem Lett V. 8 43 2017.
ISSN: ISSN 1948-5875
PubMed: 28105273
DOI: 10.1021/ACSMEDCHEMLETT.6B00281
Page generated: Thu Aug 1 11:26:29 2024
ISSN: ISSN 1948-5875
PubMed: 28105273
DOI: 10.1021/ACSMEDCHEMLETT.6B00281
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