Fluorine »
PDB 5lck-5lz4 »
5ls6 »
Fluorine in PDB 5ls6: Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Enzymatic activity of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
All present enzymatic activity of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor:
2.1.1.43;
2.1.1.43;
Protein crystallography data
The structure of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor, PDB code: 5ls6
was solved by
Y.Zhang,
N.Justin,
S.Chen,
J.Wilson,
S.Gamblin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 68.84 / 3.47 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 131.310, 170.270, 275.540, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 22.9 / 29.9 |
Other elements in 5ls6:
The structure of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor also contains other interesting chemical elements:
| Zinc | (Zn) | 32 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
(pdb code 5ls6). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor, PDB code: 5ls6:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Fluorine where determined in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor, PDB code: 5ls6:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Fluorine binding site 1 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 1 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 2 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 3 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 4 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Fluorine binding site 5 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 5 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Fluorine binding site 6 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 6 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Fluorine binding site 7 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 7 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Fluorine binding site 8 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 8 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Reference:
R.G.Vaswani,
V.S.Gehling,
L.A.Dakin,
A.S.Cook,
C.G.Nasveschuk,
M.Duplessis,
P.Iyer,
S.Balasubramanian,
F.Zhao,
A.C.Good,
R.Campbell,
C.Lee,
N.Cantone,
R.T.Cummings,
E.Normant,
S.F.Bellon,
B.K.Albrecht,
J.C.Harmange,
P.Trojer,
J.E.Audia,
Y.Zhang,
N.Justin,
S.Chen,
J.R.Wilson,
S.J.Gamblin.
Identification of (R)-N-((4-Methoxy-6-Methyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl)-2-Methyl-1-(1-(1-(2,2,2-Trifluoroethyl) Piperidin-4-Yl)Ethyl)-1H-Indole-3-Carboxamide (Cpi-1205), A Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable For Phase I Clinical Trials For B-Cell Lymphomas. J. Med. Chem. V. 59 9928 2016.
ISSN: ISSN 1520-4804
PubMed: 27739677
DOI: 10.1021/ACS.JMEDCHEM.6B01315
Page generated: Thu Aug 1 11:28:11 2024
ISSN: ISSN 1520-4804
PubMed: 27739677
DOI: 10.1021/ACS.JMEDCHEM.6B01315
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
