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Fluorine in PDB 5ls6: Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Enzymatic activity of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
All present enzymatic activity of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor:
2.1.1.43;
2.1.1.43;
Protein crystallography data
The structure of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor, PDB code: 5ls6
was solved by
Y.Zhang,
N.Justin,
S.Chen,
J.Wilson,
S.Gamblin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 68.84 / 3.47 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 131.310, 170.270, 275.540, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 22.9 / 29.9 |
Other elements in 5ls6:
The structure of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor also contains other interesting chemical elements:
| Zinc | (Zn) | 32 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
(pdb code 5ls6). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor, PDB code: 5ls6:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Fluorine where determined in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor, PDB code: 5ls6:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Fluorine binding site 1 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 1 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 2 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 3 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 4 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Fluorine binding site 5 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 5 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Fluorine binding site 6 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 6 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Fluorine binding site 7 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 7 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Fluorine binding site 8 out of 8 in 5ls6
Go back to
Fluorine Binding Sites List in 5ls6
Fluorine binding site 8 out
of 8 in the Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Structure of Human Polycomb Repressive Complex 2 (PRC2) with Inhibitor within 5.0Å range:
|
Reference:
R.G.Vaswani,
V.S.Gehling,
L.A.Dakin,
A.S.Cook,
C.G.Nasveschuk,
M.Duplessis,
P.Iyer,
S.Balasubramanian,
F.Zhao,
A.C.Good,
R.Campbell,
C.Lee,
N.Cantone,
R.T.Cummings,
E.Normant,
S.F.Bellon,
B.K.Albrecht,
J.C.Harmange,
P.Trojer,
J.E.Audia,
Y.Zhang,
N.Justin,
S.Chen,
J.R.Wilson,
S.J.Gamblin.
Identification of (R)-N-((4-Methoxy-6-Methyl-2-Oxo-1,2-Dihydropyridin-3-Yl) Methyl)-2-Methyl-1-(1-(1-(2,2,2-Trifluoroethyl) Piperidin-4-Yl)Ethyl)-1H-Indole-3-Carboxamide (Cpi-1205), A Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable For Phase I Clinical Trials For B-Cell Lymphomas. J. Med. Chem. V. 59 9928 2016.
ISSN: ISSN 1520-4804
PubMed: 27739677
DOI: 10.1021/ACS.JMEDCHEM.6B01315
Page generated: Sun Dec 13 12:27:23 2020
ISSN: ISSN 1520-4804
PubMed: 27739677
DOI: 10.1021/ACS.JMEDCHEM.6B01315
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