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Atomistry » Fluorine » PDB 5lck-5lz4 » 5lvo | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5lck-5lz4 » 5lvo » |
Fluorine in PDB 5lvo: Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-PocketEnzymatic activity of Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket
All present enzymatic activity of Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket:
2.7.11.1; Protein crystallography data
The structure of Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket, PDB code: 5lvo
was solved by
J.O.Schulze,
G.Saladino,
K.Busschots,
S.Neimanis,
E.Suess,
D.Odadzic,
S.Zeuzem,
V.Hindie,
A.K.Herbrand,
M.N.Lisa,
P.M.Alzari,
F.L.Gervasio,
R.M.Biondi,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5lvo:
The structure of Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket
(pdb code 5lvo). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket, PDB code: 5lvo: Fluorine binding site 1 out of 1 in 5lvoGo back to Fluorine Binding Sites List in 5lvo
Fluorine binding site 1 out
of 1 in the Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the Pif-Pocket
Mono view Stereo pair view
Reference:
J.O.Schulze,
G.Saladino,
K.Busschots,
S.Neimanis,
E.Su,
D.Odadzic,
S.Zeuzem,
V.Hindie,
A.K.Herbrand,
M.N.Lisa,
P.M.Alzari,
F.L.Gervasio,
R.M.Biondi.
Bidirectional Allosteric Communication Between the Atp-Binding Site and the Regulatory Pif Pocket in PDK1 Protein Kinase. Cell Chem Biol V. 23 1193 2016.
Page generated: Thu Aug 1 11:29:21 2024
ISSN: ESSN 2451-9456 PubMed: 27693059 DOI: 10.1016/J.CHEMBIOL.2016.06.017 |
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