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Atomistry » Fluorine » PDB 5lck-5lz4 » 5lxd | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5lck-5lz4 » 5lxd » |
Fluorine in PDB 5lxd: Crystal Structure of DYRK2 in Complex with Eht 1610 (Compound 2)Enzymatic activity of Crystal Structure of DYRK2 in Complex with Eht 1610 (Compound 2)
All present enzymatic activity of Crystal Structure of DYRK2 in Complex with Eht 1610 (Compound 2):
2.7.12.1; Protein crystallography data
The structure of Crystal Structure of DYRK2 in Complex with Eht 1610 (Compound 2), PDB code: 5lxd
was solved by
A.Chaikuad,
F.Von Delft,
C.H.Arrowsmith,
A.Edwards,
C.Bountra,
T.Besson,
S.Knapp,
Structural Genomics Consortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of DYRK2 in Complex with Eht 1610 (Compound 2)
(pdb code 5lxd). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of DYRK2 in Complex with Eht 1610 (Compound 2), PDB code: 5lxd: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 5lxdGo back to Fluorine Binding Sites List in 5lxd
Fluorine binding site 1 out
of 2 in the Crystal Structure of DYRK2 in Complex with Eht 1610 (Compound 2)
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 5lxdGo back to Fluorine Binding Sites List in 5lxd
Fluorine binding site 2 out
of 2 in the Crystal Structure of DYRK2 in Complex with Eht 1610 (Compound 2)
Mono view Stereo pair view
Reference:
A.Chaikuad,
J.Diharce,
M.Schroder,
A.Foucourt,
B.Leblond,
A.S.Casagrande,
L.Desire,
P.Bonnet,
S.Knapp,
T.Besson.
An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-F] Quinazoline-2-Carbimidates (Eht 1610 and Eht 5372) Confers High Selectivity For Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases. J. Med. Chem. V. 59 10315 2016.
Page generated: Sun Dec 13 12:27:33 2020
ISSN: ISSN 1520-4804 PubMed: 27766861 DOI: 10.1021/ACS.JMEDCHEM.6B01083 |
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