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Fluorine in PDB 5lz7: Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
Enzymatic activity of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
All present enzymatic activity of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2:
3.1.1.47;
3.1.1.47;
Protein crystallography data
The structure of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2, PDB code: 5lz7
was solved by
A.Woolford,
P.Day,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 32.99 / 2.10 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 99.623, 91.456, 51.413, 90.00, 112.11, 90.00 |
| R / Rfree (%) | 18 / 24.3 |
Other elements in 5lz7:
The structure of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2 also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
(pdb code 5lz7). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2, PDB code: 5lz7:
In total only one binding site of Fluorine was determined in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2, PDB code: 5lz7:
Fluorine binding site 1 out of 1 in 5lz7
Go back to
Fluorine Binding Sites List in 5lz7
Fluorine binding site 1 out
of 1 in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2 within 5.0Å range:
|
Reference:
A.J.Woolford,
P.J.Day,
V.Beneton,
V.Berdini,
J.E.Coyle,
Y.Dudit,
P.Grondin,
P.Huet,
L.Y.Lee,
E.S.Manas,
R.L.Mcmenamin,
C.W.Murray,
L.W.Page,
V.K.Patel,
F.Potvain,
S.J.Rich,
Y.Sang,
D.O.Somers,
L.Trottet,
Z.Wan,
X.Zhang.
Fragment-Based Approach to the Development of An Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2). J. Med. Chem. V. 59 10738 2016.
ISSN: ISSN 1520-4804
PubMed: 27933945
DOI: 10.1021/ACS.JMEDCHEM.6B01427
Page generated: Thu Aug 1 11:37:10 2024
ISSN: ISSN 1520-4804
PubMed: 27933945
DOI: 10.1021/ACS.JMEDCHEM.6B01427
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