Atomistry » Fluorine » PDB 5lz7-5msb » 5m7m
Atomistry »
  Fluorine »
    PDB 5lz7-5msb »
      5m7m »

Fluorine in PDB 5m7m: Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity

Enzymatic activity of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity

All present enzymatic activity of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity:
3.1.4.39;

Protein crystallography data

The structure of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity, PDB code: 5m7m was solved by A.Wolhkoning, D.Fleury, P.Leonard, N.Triballeau, P.Mollat, L.Vercheval, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 78.53 / 2.70
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 77.450, 78.890, 78.570, 90.00, 91.87, 90.00
R / Rfree (%) 22.9 / 28.4

Other elements in 5m7m:

The structure of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity also contains other interesting chemical elements:

Nickel (Ni) 7 atoms
Potassium (K) 1 atom
Zinc (Zn) 4 atoms
Iodine (I) 1 atom
Chlorine (Cl) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity (pdb code 5m7m). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity, PDB code: 5m7m:

Fluorine binding site 1 out of 1 in 5m7m

Go back to Fluorine Binding Sites List in 5m7m
Fluorine binding site 1 out of 1 in the Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F907

b:31.9
occ:1.00
F23 A:7HR907 0.0 31.9 1.0
C22 A:7HR907 1.3 30.6 1.0
C24 A:7HR907 2.4 30.2 1.0
C21 A:7HR907 2.4 29.5 1.0
CD2 A:LEU217 3.2 15.0 1.0
CG2 A:ILE168 3.3 18.6 1.0
CD1 A:ILE168 3.6 18.2 1.0
C25 A:7HR907 3.6 29.3 1.0
C20 A:7HR907 3.6 28.5 1.0
CG A:LEU217 3.8 14.5 1.0
C19 A:7HR907 4.1 28.6 1.0
CE2 A:PHE274 4.1 32.4 1.0
CB A:ILE168 4.1 18.6 1.0
CG1 A:ILE168 4.4 18.5 1.0
CD2 A:PHE274 4.6 32.3 1.0
CB A:LEU217 4.7 13.5 1.0
SD A:MET513 4.7 21.0 1.0
CE A:MET513 4.7 21.1 1.0
O A:LEU217 4.9 13.2 1.0
CD1 A:LEU217 4.9 15.0 1.0
C A:LEU217 4.9 12.7 1.0

Reference:

A.Joncour, N.Desroy, C.Housseman, X.Bock, N.Bienvenu, L.Cherel, V.Labeguere, C.Peixoto, D.Annoot, L.Lepissier, J.Heiermann, W.J.Hengeveld, G.Pilzak, A.Monjardet, E.Wakselman, V.Roncoroni, S.Le Tallec, R.Galien, C.David, N.Vandervoort, T.Christophe, K.Conrath, M.Jans, A.Wohlkonig, S.Soror, J.Steyaert, R.Touitou, D.Fleury, L.Vercheval, P.Mollat, N.Triballeau, E.Van Der Aar, R.Brys, B.Heckmann. Discovery, Structure-Activity Relationship, and Binding Mode of An Imidazo[1,2-A]Pyridine Series of Autotaxin Inhibitors. J. Med. Chem. V. 60 7371 2017.
ISSN: ISSN 1520-4804
PubMed: 28731719
DOI: 10.1021/ACS.JMEDCHEM.7B00647
Page generated: Tue Jul 15 05:12:11 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy