|
Atomistry » Fluorine » PDB 5lz5-5msa » 5m7m | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5lz5-5msa » 5m7m » |
Fluorine in PDB 5m7m: Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor ActivityEnzymatic activity of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity
All present enzymatic activity of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity:
3.1.4.39; Protein crystallography data
The structure of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity, PDB code: 5m7m
was solved by
A.Wolhkoning,
D.Fleury,
P.Leonard,
N.Triballeau,
P.Mollat,
L.Vercheval,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5m7m:
The structure of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity
(pdb code 5m7m). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity, PDB code: 5m7m: Fluorine binding site 1 out of 1 in 5m7mGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity
![]() Mono view ![]() Stereo pair view
Reference:
A.Joncour,
N.Desroy,
C.Housseman,
X.Bock,
N.Bienvenu,
L.Cherel,
V.Labeguere,
C.Peixoto,
D.Annoot,
L.Lepissier,
J.Heiermann,
W.J.Hengeveld,
G.Pilzak,
A.Monjardet,
E.Wakselman,
V.Roncoroni,
S.Le Tallec,
R.Galien,
C.David,
N.Vandervoort,
T.Christophe,
K.Conrath,
M.Jans,
A.Wohlkonig,
S.Soror,
J.Steyaert,
R.Touitou,
D.Fleury,
L.Vercheval,
P.Mollat,
N.Triballeau,
E.Van Der Aar,
R.Brys,
B.Heckmann.
Discovery, Structure-Activity Relationship, and Binding Mode of An Imidazo[1,2-A]Pyridine Series of Autotaxin Inhibitors. J. Med. Chem. V. 60 7371 2017.
Page generated: Thu Aug 1 11:37:58 2024
ISSN: ISSN 1520-4804 PubMed: 28731719 DOI: 10.1021/ACS.JMEDCHEM.7B00647 |
Last articlesCl in 4CE5Cl in 4CC7 Cl in 4CEC Cl in 4CEA Cl in 4CE3 Cl in 4CE2 Cl in 4CE1 Cl in 4CDF Cl in 4CDC Cl in 4CDU |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |