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Fluorine in PDB 5m7m: Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity
Enzymatic activity of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity
All present enzymatic activity of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity:
3.1.4.39;
3.1.4.39;
Protein crystallography data
The structure of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity, PDB code: 5m7m
was solved by
A.Wolhkoning,
D.Fleury,
P.Leonard,
N.Triballeau,
P.Mollat,
L.Vercheval,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 78.53 / 2.70 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 77.450, 78.890, 78.570, 90.00, 91.87, 90.00 |
| R / Rfree (%) | 22.9 / 28.4 |
Other elements in 5m7m:
The structure of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity also contains other interesting chemical elements:
| Nickel | (Ni) | 7 atoms |
| Potassium | (K) | 1 atom |
| Zinc | (Zn) | 4 atoms |
| Iodine | (I) | 1 atom |
| Chlorine | (Cl) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity
(pdb code 5m7m). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity, PDB code: 5m7m:
In total only one binding site of Fluorine was determined in the Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity, PDB code: 5m7m:
Fluorine binding site 1 out of 1 in 5m7m
Go back to
Fluorine Binding Sites List in 5m7m
Fluorine binding site 1 out
of 1 in the Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity within 5.0Å range:
|
Reference:
A.Joncour,
N.Desroy,
C.Housseman,
X.Bock,
N.Bienvenu,
L.Cherel,
V.Labeguere,
C.Peixoto,
D.Annoot,
L.Lepissier,
J.Heiermann,
W.J.Hengeveld,
G.Pilzak,
A.Monjardet,
E.Wakselman,
V.Roncoroni,
S.Le Tallec,
R.Galien,
C.David,
N.Vandervoort,
T.Christophe,
K.Conrath,
M.Jans,
A.Wohlkonig,
S.Soror,
J.Steyaert,
R.Touitou,
D.Fleury,
L.Vercheval,
P.Mollat,
N.Triballeau,
E.Van Der Aar,
R.Brys,
B.Heckmann.
Discovery, Structure-Activity Relationship, and Binding Mode of An Imidazo[1,2-A]Pyridine Series of Autotaxin Inhibitors. J. Med. Chem. V. 60 7371 2017.
ISSN: ISSN 1520-4804
PubMed: 28731719
DOI: 10.1021/ACS.JMEDCHEM.7B00647
Page generated: Sun Dec 13 12:27:48 2020
ISSN: ISSN 1520-4804
PubMed: 28731719
DOI: 10.1021/ACS.JMEDCHEM.7B00647
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