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Fluorine in PDB 5m8g: Tubulin-MTD265 Complex
Protein crystallography data
The structure of Tubulin-MTD265 Complex, PDB code: 5m8g
was solved by
T.Bohnacker,
A.E.Prota,
M.O.Steinmetz,
M.P.Wymann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 49.29 / 2.15 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 104.768, 157.508, 179.235, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17.1 / 20.8 |
Other elements in 5m8g:
The structure of Tubulin-MTD265 Complex also contains other interesting chemical elements:
| Magnesium | (Mg) | 5 atoms |
| Calcium | (Ca) | 5 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Tubulin-MTD265 Complex
(pdb code 5m8g). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Tubulin-MTD265 Complex, PDB code: 5m8g:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Tubulin-MTD265 Complex, PDB code: 5m8g:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 5m8g
Go back to
Fluorine Binding Sites List in 5m8g
Fluorine binding site 1 out
of 6 in the Tubulin-MTD265 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Tubulin-MTD265 Complex within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 5m8g
Go back to
Fluorine Binding Sites List in 5m8g
Fluorine binding site 2 out
of 6 in the Tubulin-MTD265 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Tubulin-MTD265 Complex within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 5m8g
Go back to
Fluorine Binding Sites List in 5m8g
Fluorine binding site 3 out
of 6 in the Tubulin-MTD265 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Tubulin-MTD265 Complex within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 5m8g
Go back to
Fluorine Binding Sites List in 5m8g
Fluorine binding site 4 out
of 6 in the Tubulin-MTD265 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Tubulin-MTD265 Complex within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 5m8g
Go back to
Fluorine Binding Sites List in 5m8g
Fluorine binding site 5 out
of 6 in the Tubulin-MTD265 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Tubulin-MTD265 Complex within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 5m8g
Go back to
Fluorine Binding Sites List in 5m8g
Fluorine binding site 6 out
of 6 in the Tubulin-MTD265 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Tubulin-MTD265 Complex within 5.0Å range:
|
Reference:
T.Bohnacker,
A.E.Prota,
F.Beaufils,
J.E.Burke,
A.Melone,
A.J.Inglis,
D.Rageot,
A.M.Sele,
V.Cmiljanovic,
N.Cmiljanovic,
K.Bargsten,
A.Aher,
A.Akhmanova,
J.F.Diaz,
D.Fabbro,
M.Zvelebil,
R.L.Williams,
M.O.Steinmetz,
M.P.Wymann.
Deconvolution of Buparlisib'S Mechanism of Action Defines Specific PI3K and Tubulin Inhibitors For Therapeutic Intervention. Nat Commun V. 8 14683 2017.
ISSN: ESSN 2041-1723
PubMed: 28276440
DOI: 10.1038/NCOMMS14683
Page generated: Thu Aug 1 11:38:34 2024
ISSN: ESSN 2041-1723
PubMed: 28276440
DOI: 10.1038/NCOMMS14683
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