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Atomistry » Fluorine » PDB 5lz5-5msa » 5mhp » |
Fluorine in PDB 5mhp: Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor ActivityEnzymatic activity of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity
All present enzymatic activity of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity:
3.1.4.39; Protein crystallography data
The structure of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity, PDB code: 5mhp
was solved by
D.Fleury,
I.Mueller,
M.Lamers,
N.Triballeau,
P.Mollat,
L.Vercheval,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5mhp:
The structure of Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity
(pdb code 5mhp). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity, PDB code: 5mhp: Fluorine binding site 1 out of 1 in 5mhpGo back to Fluorine Binding Sites List in 5mhp
Fluorine binding site 1 out
of 1 in the Novel Imidazo[1,2-A]Pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity
Mono view Stereo pair view
Reference:
N.Desroy,
C.Housseman,
X.Bock,
A.Joncour,
N.Bienvenu,
L.Cherel,
V.Labeguere,
E.Rondet,
C.Peixoto,
J.M.Grassot,
O.Picolet,
D.Annoot,
N.Triballeau,
A.Monjardet,
E.Wakselman,
V.Roncoroni,
S.Le Tallec,
R.Blanque,
C.Cottereaux,
N.Vandervoort,
T.Christophe,
P.Mollat,
M.Lamers,
M.Auberval,
B.Hrvacic,
J.Ralic,
L.Oste,
E.Van Der Aar,
R.Brys,
B.Heckmann.
Discovery of 2-[[2-Ethyl-6-[4-[2-(3-Hydroxyazetidin-1-Yl) -2-Oxoethyl]Piperazin-1-Yl]-8-Methylimidazo[1, 2-A]Pyridin-3-Yl]Methylamino]-4-(4-Fluorophenyl) Thiazole-5-Carbonitrile (GLPG1690), A First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation For the Treatment of Idiopathic Pulmonary Fibrosis. J. Med. Chem. V. 60 3580 2017.
Page generated: Thu Aug 1 11:43:24 2024
ISSN: ISSN 1520-4804 PubMed: 28414242 DOI: 10.1021/ACS.JMEDCHEM.7B00032 |
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