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Atomistry » Fluorine » PDB 5mt0-5nk2 » 5mtx » |
Fluorine in PDB 5mtx: Dibenzooxepinone Inhibitor 12B in Complex with P38 MapkEnzymatic activity of Dibenzooxepinone Inhibitor 12B in Complex with P38 Mapk
All present enzymatic activity of Dibenzooxepinone Inhibitor 12B in Complex with P38 Mapk:
2.7.11.24; Protein crystallography data
The structure of Dibenzooxepinone Inhibitor 12B in Complex with P38 Mapk, PDB code: 5mtx
was solved by
M.Buehrmann,
D.Rauh,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Dibenzooxepinone Inhibitor 12B in Complex with P38 Mapk
(pdb code 5mtx). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Dibenzooxepinone Inhibitor 12B in Complex with P38 Mapk, PDB code: 5mtx: Fluorine binding site 1 out of 1 in 5mtxGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Dibenzooxepinone Inhibitor 12B in Complex with P38 Mapk
![]() Mono view ![]() Stereo pair view
Reference:
N.M.Walter,
H.K.Wentsch,
M.Buhrmann,
S.M.Bauer,
E.Doring,
S.Mayer-Wrangowski,
A.Sievers-Engler,
N.Willemsen-Seegers,
G.Zaman,
R.Buijsman,
M.Lammerhofer,
D.Rauh,
S.A.Laufer.
Design, Synthesis, and Biological Evaluation of Novel Type I(1)/2 P38 Alpha Map Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time By Interfering with the R-Spine. J. Med. Chem. V. 60 8027 2017.
Page generated: Tue Jul 15 05:22:28 2025
ISSN: ISSN 1520-4804 PubMed: 28834431 DOI: 10.1021/ACS.JMEDCHEM.7B00745 |
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