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Fluorine in PDB 5n33: Camp-Dependent Protein Kinase A From Cricetulus Griseus in Complex with Fragment Like Molecule 3-Amino-5-(Trifluoromethyl)-1H-Pyridin-2- One
Enzymatic activity of Camp-Dependent Protein Kinase A From Cricetulus Griseus in Complex with Fragment Like Molecule 3-Amino-5-(Trifluoromethyl)-1H-Pyridin-2- One
All present enzymatic activity of Camp-Dependent Protein Kinase A From Cricetulus Griseus in Complex with Fragment Like Molecule 3-Amino-5-(Trifluoromethyl)-1H-Pyridin-2- One:
2.7.11.11;
2.7.11.11;
Protein crystallography data
The structure of Camp-Dependent Protein Kinase A From Cricetulus Griseus in Complex with Fragment Like Molecule 3-Amino-5-(Trifluoromethyl)-1H-Pyridin-2- One, PDB code: 5n33
was solved by
C.Siefker,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 41.91 / 1.43 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 58.225, 72.589, 108.793, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 15 / 17.4 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Camp-Dependent Protein Kinase A From Cricetulus Griseus in Complex with Fragment Like Molecule 3-Amino-5-(Trifluoromethyl)-1H-Pyridin-2- One
(pdb code 5n33). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Camp-Dependent Protein Kinase A From Cricetulus Griseus in Complex with Fragment Like Molecule 3-Amino-5-(Trifluoromethyl)-1H-Pyridin-2- One, PDB code: 5n33:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Camp-Dependent Protein Kinase A From Cricetulus Griseus in Complex with Fragment Like Molecule 3-Amino-5-(Trifluoromethyl)-1H-Pyridin-2- One, PDB code: 5n33:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 5n33
Go back to
Fluorine Binding Sites List in 5n33
Fluorine binding site 1 out
of 3 in the Camp-Dependent Protein Kinase A From Cricetulus Griseus in Complex with Fragment Like Molecule 3-Amino-5-(Trifluoromethyl)-1H-Pyridin-2- One
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Camp-Dependent Protein Kinase A From Cricetulus Griseus in Complex with Fragment Like Molecule 3-Amino-5-(Trifluoromethyl)-1H-Pyridin-2- One within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 5n33
Go back to
Fluorine Binding Sites List in 5n33
Fluorine binding site 2 out
of 3 in the Camp-Dependent Protein Kinase A From Cricetulus Griseus in Complex with Fragment Like Molecule 3-Amino-5-(Trifluoromethyl)-1H-Pyridin-2- One
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Camp-Dependent Protein Kinase A From Cricetulus Griseus in Complex with Fragment Like Molecule 3-Amino-5-(Trifluoromethyl)-1H-Pyridin-2- One within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 5n33
Go back to
Fluorine Binding Sites List in 5n33
Fluorine binding site 3 out
of 3 in the Camp-Dependent Protein Kinase A From Cricetulus Griseus in Complex with Fragment Like Molecule 3-Amino-5-(Trifluoromethyl)-1H-Pyridin-2- One
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Camp-Dependent Protein Kinase A From Cricetulus Griseus in Complex with Fragment Like Molecule 3-Amino-5-(Trifluoromethyl)-1H-Pyridin-2- One within 5.0Å range:
|
Reference:
C.Siefker,
A.Heine,
G.Klebe.
A Crystallographic Fragment Study with Camp-Dependent Protein Kinase A To Be Published.
Page generated: Thu Aug 1 11:55:04 2024
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