Fluorine in PDB 5nx2: Crystal Structure of Thermostabilised Full-Length Glp-1R in Complex with A Truncated Peptide Agonist at 3.7 A Resolution

The structure of Crystal Structure of Thermostabilised Full-Length Glp-1R in Complex with A Truncated Peptide Agonist at 3.7 A Resolution, PDB code: 5nx2 was solved by M.Rappas, A.Jazayeri, A.J.H.Brown, J.Kean, J.C.Errey, N.Robertson, C.Fiez-Vandal, S.P.Andrews, M.Congreve, A.Bortolato, J.S.Mason, A.H.Baig, I.Teobald, A.S.Dore, M.Weir, R.M.Cooke, F.H.Marshall, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.68 / 3.70
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	94.435, 94.435, 163.905, 90.00, 90.00, 120.00
R / Rfree (%)	28.5 / 33.4

The binding sites of Fluorine atom in the Crystal Structure of Thermostabilised Full-Length Glp-1R in Complex with A Truncated Peptide Agonist at 3.7 A Resolution (pdb code 5nx2). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Thermostabilised Full-Length Glp-1R in Complex with A Truncated Peptide Agonist at 3.7 A Resolution, PDB code: 5nx2:

Fluorine binding site 1 out of 1 in the Crystal Structure of Thermostabilised Full-Length Glp-1R in Complex with A Truncated Peptide Agonist at 3.7 A Resolution


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Thermostabilised Full-Length Glp-1R in Complex with A Truncated Peptide Agonist at 3.7 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:F5 b:0.5 occ:1.00 F47 B:9DT5 0.0 0.5 1.0 C46 B:9DT5 1.4 0.3 1.0 C45 B:9DT5 2.4 0.6 1.0 C41 B:9DT5 2.4 0.3 1.0 C40 B:9DT5 2.9 0.2 1.0 C39 B:9DT5 3.2 0.5 1.0 C38 B:9DT5 3.5 0.3 1.0 CD2 A:LEU141 3.6 0.8 1.0 O37 B:9DT5 3.6 0.7 1.0 CB A:LEU141 3.6 0.3 1.0 C44 B:9DT5 3.6 0.4 1.0 C42 B:9DT5 3.7 0.6 1.0 C36 B:9DT5 3.8 0.9 1.0 CG A:LEU141 3.9 0.2 1.0 CD1 A:LEU141 4.1 0.1 1.0 C43 B:9DT5 4.1 0.1 1.0 CA A:LEU141 4.2 0.5 1.0 O A:LEU141 4.6 0.1 1.0 CD1 A:LEU388 4.6 0.7 1.0 CD1 A:LEU144 4.6 0.1 1.0 CD1 A:LEU384 4.7 0.1 1.0 C A:LEU141 4.8 0.1 1.0 N48 B:9DT5 4.9 0.1 1.0 N B:THR6 4.9 0.9 1.0

A.Jazayeri, M.Rappas, A.J.H.Brown, J.Kean, J.C.Errey, N.J.Robertson, C.Fiez-Vandal, S.P.Andrews, M.Congreve, A.Bortolato, J.S.Mason, A.H.Baig, I.Teobald, A.S.Dore, M.Weir, R.M.Cooke, F.H.Marshall. Crystal Structure of the Glp-1 Receptor Bound to A Peptide Agonist. Nature V. 546 254 2017.
ISSN: ISSN 0028-0836
PubMed: 28562585
DOI: 10.1038/NATURE22800