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Atomistry » Fluorine » PDB 5o6j-5olv » 5o7i » |
Fluorine in PDB 5o7i: ERK5 in Complex with A Pyrrole InhibitorEnzymatic activity of ERK5 in Complex with A Pyrrole Inhibitor
All present enzymatic activity of ERK5 in Complex with A Pyrrole Inhibitor:
2.7.11.24; Protein crystallography data
The structure of ERK5 in Complex with A Pyrrole Inhibitor, PDB code: 5o7i
was solved by
J.A.Tucker,
A.Heptinstall,
S.Myers,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5o7i:
The structure of ERK5 in Complex with A Pyrrole Inhibitor also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the ERK5 in Complex with A Pyrrole Inhibitor
(pdb code 5o7i). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the ERK5 in Complex with A Pyrrole Inhibitor, PDB code: 5o7i: Fluorine binding site 1 out of 1 in 5o7iGo back to Fluorine Binding Sites List in 5o7i
Fluorine binding site 1 out
of 1 in the ERK5 in Complex with A Pyrrole Inhibitor
Mono view Stereo pair view
Reference:
S.M.Myers,
D.C.Miller,
L.Molyneux,
M.Arasta,
R.H.Bawn,
T.J.Blackburn,
S.J.Cook,
N.Edwards,
J.A.Endicott,
B.T.Golding,
R.J.Griffin,
T.Hammonds,
I.R.Hardcastle,
S.J.Harnor,
A.B.Heptinstall,
P.A.Lochhead,
M.P.Martin,
N.C.Martin,
D.R.Newell,
P.J.Owen,
L.C.Pang,
T.Reuillon,
L.J.M.Rigoreau,
H.D.Thomas,
J.A.Tucker,
L.Z.Wang,
A.C.Wong,
M.E.M.Noble,
S.R.Wedge,
C.Cano.
Identification of A Novel Orally Bioavailable ERK5 Inhibitor with Selectivity Over P38 Alpha and BRD4. Eur.J.Med.Chem. V. 178 530 2019.
Page generated: Sun Dec 13 12:29:29 2020
ISSN: ISSN 0223-5234 PubMed: 31212132 DOI: 10.1016/J.EJMECH.2019.05.057 |
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